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AUTHORS: Hsieh, Ming-Chun PhD et al Anesthesia & Analgesia February 08, 2023. BACKGROUND: The microtubule-stabilizing drug paclitaxel (PTX) is an important chemotherapeutic agent for cancer treatment and causes peripheral neuropathy as a common side effect that substantially impacts the functional status and quality of life of patients. The mechanistic role for NIMA-related kinase 2 (NEK2) […]
Read MoreAUTHORS: Zhang, Mingyue MD et al Anesthesia & Analgesia February 08, 2023. BACKGROUND: General anesthetics (eg, propofol and volatile anesthetics) enhance the slow-delta oscillations of the cortical electroencephalogram (EEG), which partly results from the enhancement of (γ-aminobutyric acid [GABA]) γ-aminobutyric acid-ergic (GABAergic) transmission. There is a GABAergic excitatory-inhibitory shift during postnatal development. Whether general anesthetics […]
Read MoreAuthor: Shahla Siddiqui, MD, MS, FCCM et al ASA Monitor July 2023, Vol. 87, 30. Although the use of positive end expiratory pressure (PEEP) for pulmonary edema was described by Barach in 1938, PEEP did not enter routine clinical practice until the late 1960s, when it was used by Gregory and colleagues in neonates with respiratory […]
Read MoreAuthor: Jenna Fletcher MedicalNewsToday February 1, 2023 There are several ways a person can help manage sciatic nerve pain at night, including adjusting sleep positions and trying pain relief remedies before bed. Sciatic nerve pain typically starts in the lower back or buttocks and radiates to the back of the thigh and legs or feet. […]
Read MoreDG Journal Club AUTHORS: Thibaut Vanneste et al Reg Anesth Pain Med. 2023 Jan 18 BACKGROUND Radiofrequency (RF) treatment of the genicular nerves has the potential to reduce chronic knee pain due to osteoarthritis or persistent postsurgical pain, however, a direct comparison between the two main modalities METHODS This double blind, non-inferiority, pilot, randomized controlled […]
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