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Uncategorized Published - 4 August, 2023    By - Dr Clemens
Associations Between Systemic and Cerebral Inflammation in an Ovine Model of Cardiopulmonary Bypass

AUTHORS: Elsaafien, Khalid PhD et al Anesthesia & Analgesia 136(4):p 802-813, April 2023. BACKGROUND: Intraoperative inflammation may contribute to postoperative neurocognitive disorders after cardiac surgery requiring cardiopulmonary bypass (CPB). However, the relative contributions of general anesthesia (GA), surgical site injury, and CPB are unclear. METHODS: In adult female sheep, we investigated (1) the temporal profile of proinflammatory […]

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Uncategorized Published - 4 August, 2023    By - Dr Clemens
Role of Tumor Necrosis Factor Receptor 1—Reactive Oxygen Species—Caspase 11 Pathway in Neuropathic Pain Mediated by HIV gp120 With Morphine in Rats

AUTHORS: Hayashi, Kentaro MD et al  Anesthesia & Analgesia 136(4):p 789-801, April 2023. BACKGROUND: Recent clinical research suggests that repeated use of opioid pain medications can increase neuropathic pain in people living with human immunodeficiency virus (HIV; PLWH). Therefore, it is significant to elucidate the exact mechanisms of HIV-related chronic pain. HIV infection and chronic morphine […]

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Uncategorized Published - 3 August, 2023    By - Dr Clemens
Validation of Automated Data Extraction From the Electronic Medical Record to Provide a Pediatric Risk Assessment Score

AUTHORS: Valencia, Eleonore MD et al  Anesthesia & Analgesia 136(4):p 738-744, April 2023. BACKGROUND: Although the rate of pediatric postoperative mortality is low, the development and validation of perioperative risk assessment models have allowed for the stratification of those at highest risk, including the Pediatric Risk Assessment (PRAm) score. The clinical application of such tools requires […]

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Uncategorized Published - 3 August, 2023    By - Dr Clemens
Undergraduate Anesthesia Skills for a Global Surgery Agenda: Students’ Self-Reported Competence

AUTHORS: Spijkerman, Sandra FCA(SA) et al  Anesthesia & Analgesia March 08, 2023.  BACKGROUND: Safe anesthesia is imperative for the Global Surgery agenda and Sustainable Development Goal 3. Due to a shortage of specialists in South Africa (SA), anesthetic services are often provided by nonspecialist doctors, often newly qualified and frequently without immediate supervision. The burden […]

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Uncategorized Published - 3 August, 2023    By - Dr Clemens
Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking

AUTHORS: Ren, Xinghua MD, PhD et al  Anesthesia & Analgesia 136(4):p 779-788, April 2023. BACKGROUND: Ketamine is an intravenous anesthetic. However, whether ketamine can induce neurotoxicity and neurobehavioral deficits remains largely unknown. Delirium is a syndrome of acute brain dysfunction associated with anesthesia and surgery in patients, and tau protein may contribute to postoperative delirium. Finally, […]

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