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Uncategorized Published - 9 August, 2023    By - Dr Clemens
Treating the heart before an attack: The surprising future of cardiac care?

MedicalNewsToday Improving outcomes for people with heart conditions was a recurring theme this week. We reported on how treatment with the “hunger hormone” ghrelin boosts pumping capacity after heart failure, and on the importance of more frequent follow-up phone calls after leaving hospital for people with heart failure. But perhaps most intriguing of all is a recent discovery that […]

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Uncategorized Published - 8 August, 2023    By - Dr Clemens
Analgesic EEffect of Buprenorphine for Chronic Noncancer Pain

AUTHORS: Wong, Stanley Sau Ching MD et al  Anesthesia & Analgesia 137(1):p 59-71, July 2023. BACKGROUND: Buprenorphine is a partial agonist at the µ-opioid receptor and an antagonist at the delta and kappa opioid receptors. It has high affinity and low intrinsic activity at the µ-opioid receptor. Buprenorphine demonstrates no ceiling effect for clinical analgesia, but […]

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Uncategorized Published - 8 August, 2023    By - Dr Clemens
Perioperative Iron Deficiency in Patients Scheduled for Major Elective Surgeries

AUTHORS: Capdevila, Xavier MD, PhD et al  Anesthesia & Analgesia 137(2):p 322-331, August 2023. BACKGROUND: The management of perioperative iron deficiency is a component of the concept of patient blood management. The objective of this study was to update French data on the prevalence of iron deficiency in patients scheduled for major surgery. METHODS: The CARENFER […]

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Uncategorized Published - 8 August, 2023    By - Dr Clemens
A Pilot Investigation Evaluating Relative Changes in Fronto-Occipital Alpha and Beta Spectral Power as Measurement of Anesthesia Hypnotic Depth

AUTHORS: Fehrlin, Eloy S. MD et al  Anesthesia & Analgesia March 24, 2023. BACKGROUND: Other than clinical observation of a patient’s vegetative response to nociception, monitoring the hypnotic component of general anesthesia (GA) and unconsciousness relies on electroencephalography (EEG)-based indices. These indices exclusively based on frontal EEG activity neglect an important observation. One of the […]

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Uncategorized Published - 8 August, 2023    By - Dr Clemens
Alfaxalone Alleviates Neurotoxicity and Cognitive Impairment Induced by Isoflurane Anesthesia in Offspring Rats

AUTHORS: Zhao, Xingkai MS et al  Anesthesia & Analgesia 136(6):p 1206-1216, June 2023. BACKGROUND: The anesthetic isoflurane can cause neurotoxicity in fetuses and offspring of rats, affecting their neurodevelopment. However, the underlying mechanisms and therapeutic targets of isoflurane-induced neurotoxicity remain to be identified. Alfaxalone (ALF) is a steroid anesthetic. Steroids have been reported to have neuroprotective […]

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