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Authors: Kristen D. Yu, M.S. et al Anesthesiology October 2023. Background Malignant hyperthermia (MH) susceptibility is a heritable musculoskeletal disorder that can present as a potentially fatal hypermetabolic response to triggering anesthesia agents. Genomic screening for variants in MH-associated genes RYR1 and CACNA1S provides an opportunity to prevent morbidity and mortality. There are limited outcomes data from disclosing variants […]
Read MoreAuthors: David W. Corpman, MD; Linda L. Liu, MD Anesthesia Patient Safety Foundation Oct 2023 Intraoperative equipment failures are increasingly rare events, but may cause serious harm based on an analysis of the American Society of Anesthesiologists (ASA) Closed Claims database.1 Pre-anesthesia checkout procedures strive to make these events preventable, but certain failures cannot be prevented […]
Read MoreAuthors: Jake Israel MD, Jeff Gudin MD. Pract Pain Manage. 2023 July/August 23(4). Test your clinical knowledge on the utility of spinal cord stimulation for treating diabetic neuropathy. Diabetic Neuropathy and Spinal Cord Stimulation: A Brief Background Diabetes is the fourth most common disease worldwide, affecting 5.9% of the world’s population.1 A common complication of the […]
Read MoreAuthors: Dibash Kumar Das, PhD; Steven L. Shafer, MD, FASA ASA Monitor October 2023, Vol. 87, 1–4. Migraine is a highly prevalent and debilitating condition affecting approximately 10%-15% of the population (Rev Neurol Aug 2023; Lancet 2012;380:2163-96). A migraine is a severe headache lasting up to 72 hours, accompanied by symptoms including nausea, vomiting, and hypersensitivity to light and sound. […]
Read MoreAuthors: Lars Heubner, MD et al Anesthesiology October 2023. Background The direct thrombin inhibitor argatroban is indicated for the treatment of heparin-induced thrombocytopenia II, but it is also used off-label to treat critically ill patients presenting with heparin resistance, severe antithrombin deficiency or hypercoagulability. Direct drug monitoring is not routinely available and argatroban dosing is […]
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