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Uncategorized Published - 23 October, 2023    By - Dr Clemens
Sedatives and Postoperative Delirium: Comment

Authors: Mark Nelson, M.D., M.Ed. et al  Anesthesiology November 2023, Vol. 139, 708. To the Editor: We read with interest the randomized controlled trial in the journal by Shin et al.  comparing postoperative delirium rates in patients undergoing major joint replacement surgery under spinal anesthesia using propofol versus dexmedetomidine sedation. Not only does this trial inform on which agent may […]

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Uncategorized Published - 20 October, 2023    By - Dr Clemens
Risk of Euglycemic Diabetic Ketoacidosis in Patients Taking Sodium Glucose Transporter 2 Inhibitors Undergoing Endoscopies

Authors: Benjamin Steinhorn, M.D., Ph.D. et al  Anesthesiology November 2023, Vol. 139, 705–707. To the Editor: Since their introduction more than a decade ago, sodium glucose transporter 2 inhibiting drugs have established themselves as important tools in the management of diabetes, chronic kidney disease, and heart failure. However, periprocedural euglycemic diabetic ketoacidosis has been associated with […]

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Uncategorized Published - 20 October, 2023    By - Dr Clemens
Severe Achalasia Could Present with Subtle Symptoms

Authors: Jan Ngian, M.B.B.S. et al  Anesthesiology November 2023, Vol. 139, 665–666. These images belong to a 30-yr-old man who underwent an arthroscopic knee meniscal repair. He had a body mass index of 29 kg/m2 and endorsed occasional mild gastroesophageal reflux after spicy food. Induction of anesthesia was unremarkable. A laryngeal mask airway (LMA) was inserted with a […]

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Uncategorized Published - 20 October, 2023    By - Dr Clemens
Indoleamine 2,3-Dioxygenase Deletion to Modulate Kynurenine Pathway and to Prevent Brain Injury after Cardiac Arrest in Mice

Authors: Aurora Magliocca, M.D., Ph.D. et al  Anesthesiology November 2023, Vol. 139, 628–645. Background The catabolism of the essential amino acid tryptophan to kynurenine is emerging as a potential key pathway involved in post–cardiac arrest brain injury. The aim of this study was to evaluate the effects of the modulation of kynurenine pathway on cardiac arrest […]

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Uncategorized Published - 20 October, 2023    By - Dr Clemens
High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8)

Authors: Nickil R Agni et al   Lancet 2023 Jul 15;402(10397):196-202. Background: Hip fracture is the most common injury requiring treatment in hospital. Controversy exists regarding the use of antibiotic loaded bone cement in hip fractures treated with hemiarthroplasty. We aimed to compare the rate of deep surgical site infection in patients receiving high-dose dual-antibiotic loaded […]

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