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Uncategorized Published - 30 October, 2023    By - Dr Clemens
Electroencephalographic Biomarkers, Cerebral Oximetry, and Postoperative Cognitive Function in Adult Noncardiac Surgical Patients

Authors: Phillip E. Vlisides, M.D. et al  Anesthesiology November 2023, Vol. 139, 568–579. Background Perioperative neurocognitive disorders are a major public health issue, although there are no validated neurophysiologic biomarkers that predict cognitive function after surgery. This study tested the hypothesis that preoperative posterior electroencephalographic alpha power, alpha frontal-parietal connectivity, and cerebral oximetry would each correlate […]

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Uncategorized Published - 27 October, 2023    By - Dr Clemens
Bispectral Index Changes Following Boluses of Commonly Used Intravenous Medications During Volatile Anesthesia Identified From Retrospective Data

AUTHORS: Schnetz, Michael P. MD, PhD et al  Anesthesia & Analgesia August 15, 2023. BACKGROUND: Although patients are commonly monitored for depth of anesthesia, it is unclear to what extent administration of intravenous anesthetic medications may affect calculated bispectral (BIS) index values under general anesthesia. METHODS: In a retrospective analysis of electronic anesthesia records from […]

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Uncategorized Published - 27 October, 2023    By - Dr Clemens
The Antinociceptive Activity of (E)-3-(thiophen-2-yl)-N-(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)-N-methyl-N-(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor

AUTHORS: Arias, Hugo R. PhD et al  Anesthesia & Analgesia 137(3):p 691-701, September 2023. BACKGROUND: The primary objective of this study was to characterize the pharmacological and behavioral activity of 2 novel compounds, DM497 [(E)-3-(thiophen-2-yl)-N-(p-tolyl)acrylamide] and DM490 [(E)-3-(furan-2-yl)-N-methyl-N-(p-tolyl)acrylamide], structural derivatives of PAM-2, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor (nAChR). METHODS: A mouse […]

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Uncategorized Published - 27 October, 2023    By - Dr Clemens
Influence of Fibrinogen Concentrate on Neonatal Clot Structure When Administered Ex Vivo After Cardiopulmonary Bypass

AUTHORS: Moiseiwitsch, Nina BS et al  Anesthesia & Analgesia 137(3):p 682-690, September 2023. BACKGROUND: Bleeding is a serious complication of cardiopulmonary bypass (CPB) in neonates. Blood product transfusions are often needed to adequately restore hemostasis, but are associated with significant risks. Thus, neonates would benefit from other effective, and safe, hemostatic therapies. The use of fibrinogen […]

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Uncategorized Published - 27 October, 2023    By - Dr Clemens
Lack of Useful Predictors of Dignity-Related Distress Among the Critically Ill as Assessed With the Patient Dignity Inventory

AUTHORS: Hadler, Rachel A. MD et al  Anesthesia & Analgesia 137(3):p 676-681, September 2023. BACKGROUND: Many intensive care unit patients are awake (ie, alert and engaging in conversation), actively experiencing many facets of their critical care. The Patient Dignity Inventory can be used to elicit sources of distress in these patients. We examined the administrative question […]

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