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Uncategorized Published - 21 December, 2023    By - Dr Clemens
Complicated Airway Management Because of Multiple Tracheal Diverticula in a Patient with Mounier–Kuhn Syndrome

Authors: Chao Liang, Ph.D. et al  Anesthesiology December 2023. A 52-yr-old man undergoing laparoscopic colectomy had a significant peritubal air leak after initiation of mechanical ventilation using a 7.5-size endotracheal tube (ETT). Peritubal air leak continued even after an 8.0-size ETT with excessive cuff inflation had been used. Multiple tracheal diverticula were detected during flexible […]

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Uncategorized Published - 21 December, 2023    By - Dr Clemens
The incidence and prevalence of pain medication prescriptions in pathologies with a potential for chronic pain.

Authors: Lisa Goudman, Ph.D. et al  Anesthesiology December 2023. Background. Heightened risks of dependence, addiction, anxiolytic effects, or prescription overdose death due to long-term use of pain medication, have increased awareness about extended pain medication use in chronic pain populations. The goal of this study was to evaluate the incidence and prevalence of pain medication […]

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Uncategorized Published - 21 December, 2023    By - Dr Clemens
Multicenter, Randomized, Placebo-Controlled Crossover Trial Evaluating Topical Lidocaine for Mechanical Cervical Pain

Authors: Steven P. Cohen, MD et al  Anesthesiology December 2023. Background There are few efficacious treatments for mechanical neck pain, with controlled trials suggesting efficacy for muscle relaxants and topical non-steroidal anti-inflammatory drugs. Although studies evaluating topical lidocaine for back pain have been disappointing, the more superficial location of the cervical musculature suggests a possible […]

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Uncategorized Published - 21 December, 2023    By - Dr Clemens
Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord

Authors: Bing Wang, Ph.D. et al  Anesthesiology December 2023. Background Endoplasmic reticulum (ER) stress plays a crucial role in the pathogenesis of neuroinflammation and chronic pain. Herein, we hypothesized that PRKR-like endoplasmic reticulum kinase (PERK) and Inositol-requiring enzyme type 1 (IRE1) regulate Lipocalin-2 (LCN2) and Nod-like receptor family pyrin domain containing 3 (NLRP3) expression in […]

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Uncategorized Published - 20 December, 2023    By - Dr Clemens
Rapid Titration of Intravenous Treprostinil to Treat Severe Pulmonary Arterial Hypertension Postpartum

AUTHORS: Wang, Tengke MD et al  Anesthesia & Analgesia 129(6):p 1607-1612, December 2019. BACKGROUND: Pulmonary hypertension during pregnancy carries high mortality rate. The relatively long-acting, specific pulmonary vasodilator treprostinil has been used to improve survival in these parturients. Slow uptitration is performed in most cases, and rapid titration has not been reported in the postpartum period. […]

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