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Uncategorized Published - 5 January, 2024    By - Dr Clemens
Updates from the Multi-center Handoff Collaborative

Authors: Aalok V. Agarwala, MD, MBA et al  The transition of responsibility and accountability for patient care from one clinical team to another is a routine part of modern health care delivery. Whether between physical locations (e.g., from the emergency department to an inpatient floor), or between teams in a static location (e.g., from a […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
Opioid Induced Respiratory Depression— Beyond Sleep Disordered Breathing

Author: Toby N. Weingarten, MD Anesthesia Patient Safety Foundation Volume 38, No. 2 • June 2023  More than a decade ago the APSF established a clear edict: “No patient should be harmed by opioid-induced respiratory depression in the postoperative period.”1 Research studies established a strong association between obstructive sleep apnea (OSA) and adverse postoperative opioid-related outcomes. In […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
A Pharmacological Evaluation of the Analgesic Effect and Hippocampal Protein Modulation of the Ketamine Metabolite (2R,6R)-Hydroxynorketamine in Murine Pain Models

AUTHORS: Das, Vaskar PhD et al  Anesthesia & Analgesia June 2023. BACKGROUND: The ketamine metabolite (2R,6R)-hydroxynorketamine ([2R,6R]-HNK) has analgesic efficacy in murine models of acute, neuropathic, and chronic pain. The purpose of this study was to evaluate the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) dependence of (2R,6R)-HNK analgesia and protein changes in the hippocampus in murine pain models administered […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Trending Ability of End-Tidal Capnography Monitoring During Mechanical Ventilation to Track Changes in Arterial Partial Pressure of Carbon Dioxide in Critically Ill Patients With Acute Brain Injury

AUTHORS: Coëffic, Adrien MD et al  Anesthesia & Analgesia June 2023. BACKGROUND: Changes in arterial partial pressure of carbon dioxide (Paco2) may alter cerebral perfusion in critically ill patients with acute brain injury. Consequently, international guidelines recommend normocapnia in mechanically ventilated patients with acute brain injury. The measurement of end-tidal capnography (Etco2) allows its approximation. […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Prevalence and Persistence of Prescription Opioid Use Following Hospital Discharge After Childbirth

AUTHORS: Varney, Bianca MIPH et al  Anesthesia & Analgesia June 2023. BACKGROUND: Opioid analgesics are used for acute postpartum pain relief but carry risks, including persistent long-term opioid use. Our primary objective was to estimate the prevalence of persistent use following hospital discharge after childbirth. METHODS: We conducted a population-based cohort study of women discharged […]

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