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Anesthesiology Published - 8 October, 2025    By - Dr Clemens
Independent CRNA Opportunity – Savannah, TN

Hardin Medical Center (122 beds) is offering a rare CRNA-only practice with full autonomy and an unbeatable lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off annually)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, ortho, endo, OB/GYN (epidurals & C-sections)• No Complex Cases: No hearts, no […]

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Anesthesiology Published - 7 October, 2025    By - Dr Clemens
Topical Analgesics: Pharmacology and Clinical Applications

Authors: Sisignano, Marco et al. Anesthesiology, September 18, 2025. DOI: 10.1097/ALN.0000000000005579 This comprehensive review explores the pharmacology, mechanisms of action, and clinical applications of topical analgesics—agents that deliver localized pain relief with minimal systemic side effects. These formulations are particularly useful when oral administration is impractical due to gastrointestinal issues or when pain is localized, […]

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Anesthesiology Published - 7 October, 2025    By - Dr Clemens
Bispectral Index–Guided Anesthesia for Older Patients Having Non-Cardiac Surgery

Author: Zhou, Li et al. Anesthesiology ():10.1097/ALN.0000000000005770, September 25, 2025. doi:10.1097/ALN.0000000000005770 This large multicenter, randomized, double-blind trial tested whether Bispectral Index (BIS) monitoring improves long-term outcomes in older adults undergoing elective non-cardiac surgery. The study included 6,982 patients aged 65 years or older across 21 hospitals in China. Patients were randomized to BIS-guided anesthesia (maintaining […]

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Anesthesiology Published - 7 October, 2025    By - Dr Clemens
Revisiting infusion rate limitations for continuous lumbar plexus blocks in children and adolescents with 0.2% ropivacaine

Author: Sunder, Rani A. et al. Anesthesiology ():10.1097/ALN.0000000000005775, September 29, 2025. doi:10.1097/ALN.0000000000005775 This study evaluated the pharmacokinetics of ropivacaine and its metabolite PPX in children receiving lumbar plexus blocks. Twenty patients aged 4–18 years underwent hip or femur surgery with a 2 mg/kg bolus of 0.2% ropivacaine followed by a 0.4 mg/kg/h infusion. Blood sampling […]

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Anesthesiology Published - 7 October, 2025    By - Dr Clemens
The Landscape of Anesthesiology Perioperative Interventional Clinical Trials Registered in ClinicalTrials.gov

Author: Kantheti HS et al. Anesthesiology, September 12, 2025. doi:10.1097/ALN.0000000000005750 This study analyzed perioperative clinical trials registered in ClinicalTrials.gov between 2008 and 2022, comparing anesthesiology-related studies with non-anesthesiology trials. Of nearly 281,000 trials, only 6,602 (2.4%) were anesthesia-related. Encouragingly, the proportion of anesthesiology trials increased from 1.5% in 2008 to 2.7% in 2022 (p<0.001). Anesthesiology […]

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