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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Quercetin, Main Active Ingredient of Moutan Cortex, Alleviates Chronic Orofacial Pain via Block of Voltage-Gated Sodium Channel

AUTHORS: Liu, Zhanli MD et al  Anesthesia & Analgesia November 17, 2023. BACKGROUND: Chronic orofacial pain (COP) therapy is challenging, as current medical treatments are extremely lacking. Moutan Cortex (MC) is a traditional Chinese medicine herb widely used for chronic inflammatory diseases. However, the mechanism behind MC in COP therapy has not been well-established. The […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Low Perfusion and Missed Diagnosis of Hypoxemia by Pulse Oximetry in Darkly Pigmented Skin

AUTHORS: Gudelunas, M. Koa BS et al  Anesthesia & Analgesia 138(3):p 552-561, March 2024. BACKGROUND: Retrospective clinical trials of pulse oximeter accuracy report more frequent missed diagnoses of hypoxemia in hospitalized Black patients than White patients, differences that may contribute to racial disparities in health and health care. Retrospective studies have limitations including mistiming of blood […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Novel Preoperative Risk Stratification Using Digital Phenotyping Applying a Scalable Machine-Learning Approach

AUTHORS: Laferrière-Langlois, Pascal MD, MS et al  Anesthesia & Analgesia December 05, 2023. | BACKGROUND: Classification of perioperative risk is important for patient care, resource allocation, and guiding shared decision-making. Using discriminative features from the electronic health record (EHR), machine-learning algorithms can create digital phenotypes among heterogenous populations, representing distinct patient subpopulations grouped by shared characteristics, […]

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Uncategorized Published - 29 February, 2024    By - Dr Clemens
Poor Agreement Between Preoperative Transthoracic Echocardiography and Intraoperative Transesophageal Echocardiography for Grading Diastolic Dysfunction

AUTHORS: McIlroy, David R. MBBS, MD, MClinEpi, FANZCA et al  Anesthesia & Analgesia 138(1):p 123-133, January 2024. BACKGROUND: Guidelines for the evaluation and grading of diastolic dysfunction are available for transthoracic echocardiography (TTE). Transesophageal echocardiography (TEE) is used for this purpose intraoperatively but the level of agreement between these 2 imaging modalities for grading diastolic dysfunction […]

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Uncategorized Published - 29 February, 2024    By - Dr Clemens
Association Between Loop Diuretics and Mortality in Patients With Cardiac Surgery–Associated Acute Kidney Injury

AUTHORS: Zhu, Shouqiang MD et al Anesthesia & Analgesia November 22, 2023. BACKGROUND: Although loop diuretics (LDs) have been widely used in clinical practice, their effect on mortality when administered to patients experiencing cardiac surgery–associated acute kidney injury (CS-AKI) remains unknown. The study aimed to investigate the effectiveness of LD use in patients with CS-AKI. […]

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