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Authors: Marie Pollak, M.D. et al Anesthesiology May 2024, Vol. 140, 979–989. Background Postoperative delirium is a common complication in elderly patients undergoing anesthesia. Even though it is increasingly recognized as an important health issue, the early detection of patients at risk for postoperative delirium remains a challenge. This study aims to identify predictors of postoperative […]
Read MoreAuthors: Melody Reese, Ph.D. et al Anesthesiology May 2024, Vol. 140, 963–978. Background Anesthesia and/or surgery accelerate Alzheimer’s disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) Alzheimer’s disease–related biomarker and cognitive trajectories in older adults who underwent surgery versus those who have not. Thus, the […]
Read MoreAuthor: Michael R. Fettiplace, M.D., Ph.D. Anesthesiology May 2024, Vol. 140, 868–870. “[As] evidence accumulates, we find that the biologic plausibility of liposomal bupivacaine does not translate into clinical relevance.” For over a century, anesthesiologists have sought to extend the utility, duration, and safety of local anesthetics, from the original topical instillation of cocaine onto the […]
Read MoreAnesthesiology May 2024, Vol. 140, A13–A15. Cortical regulation of helping behaviour towards others in pain. Nature 2024; 626:136–44. PMID: 38267578. Article Selection: Cyril Rivat, Ph.D. Image: Adobe Stock. Prosocial behaviors are pivotal for promoting survival and social cohesion among animals. Injury triggers instinctive responses alleviating pain and reducing infection risks through behaviors like licking. In social […]
Read MoreAnesthesiology May 2024, Vol. 140, A13–A15. The impact of bed rest on human skeletal muscle metabolism. Cell Rep Med 2024; 5:101372. PMID: 38232697. Article Selection: Charles Emala, M.D. Image: Adobe Stock. Prolonged physical inactivity results in detrimental alterations in many physiologic processes including insulin insensitivity, but the kinetics and cellular mechanisms of these changes in human […]
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