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Uncategorized Published - 29 May, 2024    By - Dr Clemens
Novel Resuscitation Strategies in Severe Trauma: Comment

Authors: John J. Kowalczyk, M.D.; Michaela K. Farber, M.D., M.S. Anesthesiology June 2024, Vol. 140, 1237–1238. To the Editor: We read with great interest the review of “Early Fibrinogen Replacement to Treat the Endotheliopathy of Trauma: Novel Resuscitation Strategies in Severe Trauma” by Douin et al.  This article explores endothelial dysfunction that can occur with the coagulopathy of trauma, […]

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Uncategorized Published - 29 May, 2024    By - Dr Clemens
American Society of Anesthesiologists 2023 Guidance on Neurologic Complications of Neuraxial Analgesia/Anesthesia in Obstetrics

Authors: Manuel C. Vallejo, M.D., D.M.D. et al  Anesthesiology June 2024, Vol. 140, 1235–1236. To the Editor: Both parturients and healthcare providers have fears of neurologic complications associated with neuraxial analgesia/anesthesia, even though the odds are 5- to 10-fold higher for obstetric-related injury. More than half of parturients want to be informed of anesthetic risks even […]

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Uncategorized Published - 29 May, 2024    By - Dr Clemens
Combined Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Surgery of the Foot or Ankle

Authors: Mathias Maagaard, M.D. et al  Anesthesiology June 2024, Vol. 140, 1165–1175. Background Both dexamethasone and dexmedetomidine increase the duration of analgesia of peripheral nerve blocks. The authors hypothesized that combined intravenous dexamethasone and intravenous dexmedetomidine would result in a greater duration of analgesia when compared with intravenous dexamethasone alone and placebo. Methods The authors randomly […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Antithrombin Levels and Heparin Responsiveness during Venoarterial Extracorporeal Membrane Oxygenation

Authors: Alexandre Mansour, M.D., Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1153–1164. Background Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent on extracorporeal membrane oxygenation; however, its association with acquired antithrombin deficiency is poorly understood. The objective […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Dexmedetomidine Inhibits Paraventricular Corticotropin-releasing Hormone Neurons that Attenuate Acute Stress-induced Anxiety-like Behavior in Mice

Authors: Gaolin Qiu, M.D. et al  Anesthesiology June 2024, Vol. 140, 1134–1152. Background Dexmedetomidine has repeatedly shown to improve anxiety, but the precise neural mechanisms underlying this effect remain incompletely understood. This study aims to explore the role of corticotropin-releasing hormone–producing hypothalamic paraventricular nucleus (CRHPVN) neurons in mediating the anxiolytic effects of dexmedetomidine. Methods A social […]

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