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Uncategorized Published - 20 June, 2024    By - Dr Clemens
μ-Opioid Receptor Activation at the Dorsal Reticular Nucleus Shifts Diffuse Noxious Inhibitory Controls to Hyperalgesia in Chronic Joint Pain in Male Rats

Authors: Raquel Pereira-Silva, Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1176–1191. Background The dorsal reticular nucleus is a pain facilitatory area involved in diffuse noxious inhibitory control (DNIC) through opioidergic mechanisms that are poorly understood. The hypothesis was that signaling of μ-opioid receptors is altered in this area with prolonged chronic inflammatory pain and that […]

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Uncategorized Published - 19 June, 2024    By - Dr Clemens
What Is the Role of a Periarticular Injection for Knee Arthroplasty Patients Receiving a Multimodal Analgesia Regimen Incorporating Adductor Canal and Infiltration Between the Popliteal Artery and Capsule of the Knee Blocks?

AUTHORS: YaDeau, Jacques T. MD, PhD et al  Anesthesia & Analgesia 138(6):p 1163-1172, June 2024. BACKGROUND: Optimal analgesic protocols for total knee arthroplasty (TKA) patients remain controversial. Multimodal analgesia is advocated, often including peripheral nerve blocks and/or periarticular injections (PAIs). If 2 blocks (adductor canal block [ACB] plus infiltration between the popliteal artery and capsule of […]

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Uncategorized Published - 19 June, 2024    By - Dr Clemens
An Evolving Framework for Using Big Data Tools and Machine Learning to Enhance Perioperative Quality Improvement, Research, and Patient Safety

Authors: Michael R. Mathis, MD et al  Anesthesia Patient Safety Foundation June 2024 Volume 39, No. 2  In an era of near-complete adoption of electronic health records (EHRs) and coalescence of health data across departments and institutions, a growing recognition of practice variation has emerged. Perioperative care is no exception, with recent studies demonstrating wide […]

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Uncategorized Published - 19 June, 2024    By - Dr Clemens
Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats

Authors: L Niklas Daniel Åke Persson, M.Sc. et al  Anesthesiology May 2024. Background Impaired glymphatic clearance of cerebral metabolic products and fluids contribute to traumatic and ischemic brain oedema and neurodegeneration in preclinical models. Glymphatic perivascular cerebrospinal fluid (CSF) flow varies between anesthetics possibly due to changes in vasomotor tone and thereby in the dynamics […]

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Uncategorized Published - 19 June, 2024    By - Dr Clemens
The Color of Climate Change: Can Choice of Anesthetic Be Institutionally Racist?

Authors: Baker, Maxwell B. MSc et al  Anesthesia & Analgesia 138(6):p 1154-1158, June 2024. | In the United States, the health care sector is responsible for 10% of the nation’s carbon emissions.1 Anesthesia-related care is responsible for 5% of total health care carbon emissions.2 Within hospitals themselves, as much as 33% of waste is produced by perioperative services.3 Medical […]

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