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Uncategorized Published - 26 June, 2024    By - Dr Clemens
Science, Medicine, and the Anesthesiologist

Author: Charles Emala, M.D. Anesthesiology July 2024, Vol. 141, A13–A15. Capillary oxygen regulates demand-supply coupling by triggering connexin40-meidated conduction: Rethinking the metabolic hypothesis. Proc Natl Acad Sci USA 2024; 121:e2303119121. PMID: 38349880. Tissue oxygen delivery requires localized sensing of oxygen demand that dictates upstream arteriolar dilation. Microvascular blood flow is closely matched to tissue oxygen requirements […]

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Uncategorized Published - 25 June, 2024    By - Dr Clemens
Effects of an Early Intensive Blood Pressure–lowering Strategy Using Remifentanil and Dexmedetomidine in Patients with Spontaneous Intracerebral Hemorrhage

Authors: Rui Dong, M.M. et al  Anesthesiology July 2024, Vol. 141, 100–115. Background Although it has been established that elevated blood pressure and its variability worsen outcomes in spontaneous intracerebral hemorrhage, antihypertensives use during the acute phase still lacks robust evidence. A blood pressure–lowering regimen using remifentanil and dexmedetomidine might be a reasonable therapeutic option given […]

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Uncategorized Published - 25 June, 2024    By - Dr Clemens
Fibrinolysis as a Causative Mechanism for Bleeding Complications on Extracorporeal Membrane Oxygenation

Authors: Julie Helms, M.D., Ph.D. et al  Anesthesiology July 2024, Vol. 141, 75–86. Background Extracorporeal membrane oxygenation (ECMO) is associated with a high risk of bleeding complications. The specific impact of ECMO on fibrinolysis remains unexplored. The objective of the current pilot observational prospective study was to investigate the longitudinal dynamics of fibrinolytic markers—i.e., changes over […]

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Uncategorized Published - 25 June, 2024    By - Dr Clemens
Increasing Sweep Gas Flow Reduces Respiratory Drive and Dyspnea in Nonintubated Venoarterial Extracorporeal Membrane Oxygenation Patients

Authors: Côme Bureau, M.D., Ph.D. et al  Anesthesiology July 2024, Vol. 141, 87–99. Background Data on assessment and management of dyspnea in patients on venoarterial extracorporeal membrane oxygenation (ECMO) for cardiogenic shock are lacking. The hypothesis was that increasing sweep gas flow through the venoarterial extracorporeal membrane oxygenator may decrease dyspnea in nonintubated venoarterial ECMO patients […]

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Uncategorized Published - 25 June, 2024    By - Dr Clemens
A Comparison of Five Algorithmic Methods and Machine Learning Pattern Recognition for Artifact Detection in Electronic Records of Five Different Vital Signs

Authors: Mathias Maleczek, M.D. et al  Anesthesiology July 2024, Vol. 141, 32–43. Background Research on electronic health record physiologic data is common, invariably including artifacts. Traditionally, these artifacts have been handled using simple filter techniques. The authors hypothesized that different artifact detection algorithms, including machine learning, may be necessary to provide optimal performance for various vital […]

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