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Uncategorized Published - 5 May, 2015    By - Dr Clemens
Is the serum level of reactive oxygen metabolites appropriate for evaluating short-term surgical stress of patients undergoing colectomy?

Publsihed in Int Surg. 2015 Apr;100(4):770-2. Authors: Fujita F et al To demonstrate whether reactive oxygen and free radical measuring are appropriate to evaluate short-term surgical stress after laparoscopic colectomy. The subjects consisted of 22 cases (laparoscopic surgery, 16; and laparotomy, 6) that underwent surgery for colon cancer. The reactive oxygen metabolites (ROM) value in the […]

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Uncategorized Published - 5 May, 2015    By - Dr Clemens
Transfusion Threshold for Abdominal Cancer Surgery Patients

Authors: Pinheiro de Almeida J et al., Anesthesiology 2015 Jan 122:29 A hemoglobin level of 9 g/dL was superior to 7 g/dL as a trigger for transfusion. Randomized trials have shown favorable outcomes with a restrictive red-cell transfusion strategy — that is, not transfusing until hemoglobin levels are <7 g/dL in general critical-care patients (NEJM JW Gen […]

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Uncategorized Published - 5 May, 2015    By - Dr Clemens
Population pharmacokinetic model of free and total ropivacaine after TAP nerve block in patients undergoing liver resection.

Published in Br J Clin Pharmacol. 2014 Dec 31 Authors: Ollier E et al AIM: The aim of this study was to develop a pharmacokinetic model in order to characterise the free and total ropivacaine concentrations after TAP block in a population of patients undergoing liver resection surgery. In particular, we evaluated the impact of the […]

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Uncategorized Published - 5 May, 2015    By - Dr Clemens
Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity.

Published in Br J Clin Pharmacol. 2014 Dec 30. Authors: Mouly S et AIMS: Methadone is characterized by wide intersubject variability regarding the dose needed to obtain full therapeutic response. We assessed the influence of sociodemographic, ethnic, clinical, metabolic & genotype variables on methadone maintenance dose requirement in opioid-dependent responder patients. METHODS: Eighty-one stable patients (60 […]

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Uncategorized Published - 4 May, 2015    By - Dr Clemens
Trends in opioid analgesic abuse and mortality in the United States.

Published in N Engl J Med. 2015 Jan 15;372(3):241-8 Authors: Dart RC et al BACKGROUND: The use of prescription opioid medications has increased greatly in the United States during the past two decades; in 2010, there were 16,651 opioid-related deaths. In response, hundreds of federal, state, and local interventions have been implemented. We describe trends in […]

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