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Can J Anaesth 2015 Aug;62(8):891-900 Authors: West N et al PURPOSE: Morphine administered by continuous opioid infusion (COI) or by patient-controlled analgesia (PCA) is associated with opioid-induced pruritus (OIP). Intravenous naloxone administered separately to the morphine infusion at a dose of 0.25-1.65 μg·kg-1·hr-1 can provide effective prevention from OIP. Nevertheless, this strategy requires a dedicated intravenous line and […]
Read MoreCan J Anaesth. 2015 Jul;62(7):816-829 Authors: Liu ZX et al PURPOSE: Shivering is a frequent complication in the postoperative period. The aim of the current meta-analysis was to assess the efficacy of dexmedetomidine on postoperative shivering. METHODS: Two researchers independently searched PubMed, EMBASE™ and the Cochrane Central Register of Controlled Trials for controlled clinical trials. The meta-analysis […]
Read MoreJAMA Intern Med. 2015 Jun;175(6):978-87 Authors: Larochelle MR et al IMPORTANCE: In the second half of 2010, abuse-deterrent extended-release oxycodone hydrochloride (OxyContin; Purdue Pharma) was introduced and propoxyphene was withdrawn from the US market. The effect of these pharmaceutical market changes on opioid dispensing and overdose rates is unknown. OBJECTIVE: To evaluate the association between 2 temporally […]
Read MorePediatr Blood Cancer. 2015 Jul;62(7):1237-44 Authors: Anghelescu DL et al BACKGROUND: Patient controlled anesthesia (PCA) is increasingly used to manage pain in pediatric cancer patients and is important in the treatment of escalating pain at the end of life. The description of the use of opioid PCA in this population has been limited. PROCEDURE: This retrospective […]
Read MoreA retrospective comparison of infants and children sedated using propofol or dexmedetomidine has implicated propofol with the more rapid induction of anaesthesia and quicker recovery from sedation, researchers reported here at the 2015 Annual Meeting of the Pediatric Academic Societies (PAS). However, while propofol may be an alternative to dexmedetomidine, its benefits come with the […]
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