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Anesthesiology 10 2015, Vol.123, 810-819 Authors: Creed M. Stary, MD, PhD et al Background: Isoflurane induces cell death in neurons undergoing synaptogenesis via increased production of pro-brain–derived neurotrophic factor (proBDNF) and activation of postsynaptic p75 neurotrophin receptor (p75NTR). Astrocytes express p75NTR, but their role in neuronal p75NTR-mediated cell death remains unclear. The authors investigated whether astrocytes have the capacity […]
Read MoreAnesthesiology 9 2015, Vol.123, 524-534 Authors: Chris H. Martini MD et al ; Background: A novel multidimensional index of nociception, the nociception level (NoL) index, derived from the nonlinear composite of heart rate (HR), HR variability, amplitude of the photoplethysmogram, skin conductance, fluctuations in skin conductance, and their time derivatives, was used to assess nociception during anesthesia. Methods: Seventy-two […]
Read MoreAnesthesiology 9 2015, Vol.123, 515-523 Authors: Louise Y. Sun MD, PhD, et al Background: Intraoperative hypotension (IOH) may be associated with postoperative acute kidney injury (AKI), but the duration of hypotension for triggering harm is unclear. The authors investigated the association between varying periods of IOH with mean arterial pressure (MAP) less than 55, less than 60, and […]
Read MoreAnesthesiology 9 2015, Vol.123, 507-514 Authors: Eric C. Sun MD, PhD et al Background: Markets for physician services are becoming increasingly concentrated, with many areas being dominated by a few groups. Antitrust authorities are concerned that increasing concentration will lead to inappropriately high payments for physician services from private insurers. The authors examined the association between market concentration […]
Read MoreAnesthesiology 9 2015, Vol.123, 501-503 Authors: Goran Hedenstierna MD PhD Mechanical ventilation may cause harm to the lung, at least if the lung is already hurt as is the case in intensive care. Can it be harmful also when ventilating the “lung-healthy” patient during anesthesia? Probably not during anesthesia alone, as suggested by animal experiments on […]
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