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Uncategorized Published - 30 November, 2015    By - Dr Clemens
Inflammation Increases Neuronal Sensitivity to General Anesthetics

Authors: Sinziana Avramescu, MD, PhD, et al Anesthesiology published on 11 2015. Background: Critically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms remain poorly understood. Inflammation increases the number of γ-aminobutyric acid type A (GABAA) receptors expressed on the surface of neurons, which supports the hypothesis that inflammation increases up-regulation […]

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Uncategorized Published - 30 November, 2015    By - Dr Clemens
Morbidity and Mortality after High-dose Transfusion

Authors: Daniel J. Johnson, B.S. el at Anesthesiology published on 11 2015. Background: It is well recognized that increased transfusion volumes are associated with increased morbidity and mortality, but dose–response relations between high- and very-high-dose transfusion and clinical outcomes have not been described previously. In this study, the authors assessed (1) the dose–response relation over a wide […]

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Uncategorized Published - 30 November, 2015    By - Dr Clemens
Impact of Perioperative Epidural Placement on Postdischarge Opioid Use in Patients Undergoing Abdominal Surgery

Authors: Karim S. Ladha, MD M.Sc et al Anesthesiology published on 11 2015. Background: Opioids play a crucial role in providing analgesia throughout the perioperative period; however, patients may become persistent users of these medications months after surgery. Epidurals have been posited to prevent the development of persistent pain, but there are little data on the effect […]

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Uncategorized Published - 27 November, 2015    By - Dr Clemens
Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

Authors: Lisbeth Evered, B.Sc, M.Biostat, PhD et al Anesthesiology published on 11 2015. Background: Postoperative cognitive dysfunction (POCD) affects 16 to 21% of the elderly 3 months after anesthesia and surgery and is associated with adverse outcomes. The exact cause of POCD remains unknown. The authors hypothesized that elderly individuals with Alzheimer disease (AD) neuropathology, identified by cerebrospinal […]

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Uncategorized Published - 27 November, 2015    By - Dr Clemens
Psychiatric Disorders and Psychopharmacologic Treatment as Risk Factors in Elective Fast-track Total Hip and Knee Arthroplasty

Authors: Christoffer C. Jorgensen MD, et al Anesthesiology 12 2015, Vol.123, 1281-1291. doi:10.1097/ALN.0000000000000632 Background: Psychiatric disorder (PsD) is rarely considered when evaluating perioperative risk factors. Studies on PsD are often limited by use of administrative coding, incomplete follow-up, and lack of preoperative data on psychopharmacological treatment. Methods: A multicenter study with prospective registration on preoperative comorbidity, complete 90-day follow-up, […]

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