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Painful diabetic peripheral neuropathy (DPN) can be effectively treated with hepatocyte growth factor gene therapy, according to results of a phase 2 clinical trial presented at the 140th Annual Meeting of the American Neurological Association (ANA). “Diabetic peripheral neuropathy can cause debilitating pain with no effective treatment, and hepatocyte growth factor has potent neurotropic and […]
Read MoreVery low frequency (<2 Hz) stimulation may be more effective at controlling neuropathic pain in patients with spinal-cord injury than higher frequencies (>10 Hz), according to a small, 2-subject study presented on September 28 at the 140th Annual Meeting of the American Neurological Association (ANA). Corneliu Luca MD, PhD, University of Miami Health System, Miami, […]
Read MoreHeadache, 2015 Oct;55(9):1192-208. Authors: Johnson JL et al BACKGROUND: Medication overuse headache (MOH) is a condition bordering between a chronic pain condition and a substance dependence disorder. Activation of immunocompetent glial cells in the central nervous system has been linked to both pathological pain and drug addiction/reward. Preclinically, ibudilast attenuates glial activation and is able to reduce […]
Read MoreJ Arthroplasty, 2015 Sep;30 Authors: Schroer WC et al Liposomal bupivacaine periarticular injection (PAI) offers sustained bupivacaine release after TKA, but few prospective independent studies exist. In this prospective, blinded study, liposomal bupivacaine was randomized against bupivacaine and incorporated into a comprehensive multimodal pain management protocol. 111 primary TKAs were randomized to receive PAI: 58 patients received […]
Read MoreWhat Is Now Available and Efficacious? Authors: J. W. Sear et al Br J Anaesth. 2015;115(3):333-336. Publication, in 2008, of the results of POISE, the largest randomized controlled trial (RCT) of perioperative beta-blockade, confirmed previous studies that had shown beta-blockade to offer cardiac protection in patients with, or at risk for, coronary heart disease.[1] However, this protection […]
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