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Uncategorized Published - 14 September, 2016    By - Dr Clemens
STR-324, a Stable Analog of Opiorphin, Causes Analgesia in Postoperative Pain by Activating Endogenous Opioid Receptor–dependent Pathways

Authors: Philippe Sitbon, M.D. et al   Anesthesiology published on September 1, 2016 Background: Opiorphin is a naturally occurring potent analgesic human peptide. It protects enkephalins from degradation and inhibits pain perception in various acute pain models via activation of endogenous opioid pathways. However, the efficacy of opiorphin continuous infusion and its chemically stable form, STR-324, in postoperative […]

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Uncategorized Published - 13 September, 2016    By - Dr Clemens
Combined Spinal Epidural Technique for Labor Analgesia Does Not Delay Recognition of Epidural Catheter Failures: A Single-center Retrospective Cohort Survival Analysis

Authors: Jessica M. Booth, M.D. et al Anesthesiology 9 2016, Vol.125, 516-524. Background: It is unclear whether recognition of epidural catheter failures is delayed with combined spinal epidural technique (CSE) compared to traditional epidural technique (EPID) when used for labor analgesia. The authors hypothesized that recognition of failed catheters is not delayed by CSE. Methods: Anesthetic, obstetric, and […]

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Uncategorized Published - 13 September, 2016    By - Dr Clemens
Pulmonary Embolism in Acute Exacerbations of COPD

Aleva FE et al., Chest 2016 Aug 12; This systematic review shows a high rate of PE in patients hospitalized for exacerbation of chronic obstructive pulmonary disease. Pulmonary embolism (PE) is a notoriously difficult clinical diagnosis, and symptoms of PE can overlap with those of acute exacerbations of chronic obstructive pulmonary disease (COPD). Further, the inflammation of […]

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Uncategorized Published - 13 September, 2016    By - Dr Clemens
Does CPAP Reduce Cardiovascular Risk?

Harlan M. Krumholz, MD, SM Reviewing McEvoy RD et al., N Engl J Med 2016 Aug 28; In a multicenter trial, patients with cardiovascular disease and obstructive sleep apnea had no reduction in risk. Continuous positive airway pressure (CPAP) is a common treatment for obstructive sleep apnea, a risk factor for cardiovascular disease. However, little is known about […]

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Uncategorized Published - 13 September, 2016    By - Dr Clemens
Migraine in Kids Linked to Functional GI Disorders

Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS Migraine in children is associated with increased risk for functional gastrointestinal disorders, according to a case-control study in the Lancet Gastroenterology & Hepatology. Researchers studied 425 children aged 6–17 years who were diagnosed with migraine or tension-type headache in the emergency department, and 650 children who […]

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