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Uncategorized Published - 22 December, 2016    By - Dr Clemens
Study Finds Rising Rates of Children Hospitalized for Opioid Poisonings

Beyond the rising rates of deaths related to opioid use, a new analysis of hospital records shows significantly higher rates also affecting children being hospitalized for opioid poisoning Interview with Julie R. Gaither, PhD, MPH, RN and G. Caleb Alexander, MD, MS As the deadly consequences of opioid abuse in the US remain in the […]

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Uncategorized Published - 22 December, 2016    By - Dr Clemens
Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy

Authors: Ross A. Davenport, Ph.D. et al   Anesthesiology 1 2017, Vol.126, 115-127. Background: Major trauma is a leading cause of morbidity and mortality worldwide with hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy exacerbates bleeding, but controversy remains over the degree to which inhibition of procoagulant pathways (anticoagulation), fibrinogen loss, and fibrinolysis drive the […]

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Uncategorized Published - 22 December, 2016    By - Dr Clemens
Withholding versus Continuing Angiotensin-converting Enzyme Inhibitors or Angiotensin II Receptor Blockers before Noncardiac Surgery: An Analysis of the Vascular events In noncardiac Surgery patIents

Authors: Pavel S. Roshanov, M.D., M.Sc. et al Anesthesiology 1 2017, Vol.126, 16-27 Background: The effect on cardiovascular outcomes of withholding angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac surgery is unknown. Methods: In this international prospective cohort study, the authors analyzed data from 14,687 patients (including 4,802 angiotensin-converting enzyme inhibitor/angiotensin II receptor […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Extubation Failure in Brain-injured Patients: Risk Factors and Development of a Prediction Score in a Preliminary Prospective Cohort Study

Authors: Thomas Godet, M.D., Ph.D. et al Anesthesiology 1 2017, Vol.126, 104-114. Background: The decision to extubate brain-injured patients with residual impaired consciousness holds a high degree of uncertainty of success. The authors developed a pragmatic clinical score predictive of extubation failure in brain-injured patients. Methods: One hundred and forty brain-injured patients were prospectively included after the first […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury

Authors: Jukka Kortelainen, M.D., Ph.D. et al Anesthesiology 1 2017, Vol.126, 94-103. Background: Slow waves (less than 1 Hz) are the most important electroencephalogram signatures of nonrapid eye movement sleep. While considered to have a substantial importance in, for example, providing conditions for single-cell rest and preventing long-term neural damage, a disturbance in this neurophysiologic phenomenon is […]

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