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Uncategorized Published - 14 November, 2016    By - Dr Clemens
Median Effective Dose of Intranasal Dexmedetomidine for Rescue Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging

Authors: Wenhua Zhang, M.D. et al Anesthesiology 12 2016, Vol.125, 1130-1135. Background: The median effective dose (ED50) of intranasal dexmedetomidine after failed chloral hydrate sedation has not been described for children. This study aims to determine the ED50 of intranasal dexmedetomidine for rescue sedation in children aged 1 to 36 months, who were inadequately sedated by chloral hydrate […]

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Uncategorized Published - 14 November, 2016    By - Dr Clemens
Perioperative Aspirin for Prevention of Venous Thromboembolism: The PeriOperative ISchemia Evaluation-2 Trial and a Pooled Analysis of the Randomized Trials

Authors: John W. Eikelboom, M.B.B.S. et al Anesthesiology 12 2016, Vol.125, 1121-1129 Background: The PeriOperative ISchemia Evaluation-2 (POISE-2) trial compared aspirin with placebo after noncardiac surgery. Methods: The authors randomly assigned 10,010 patients undergoing noncardiac surgery to receive 200 mg aspirin or placebo 2 to 4 h before surgery and then 100 mg aspirin daily or placebo daily for up to 30 days after […]

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Uncategorized Published - 14 November, 2016    By - Dr Clemens
Effectiveness of an Electronic Alert for Hypotension and Low Bispectral Index on 90-day Postoperative Mortality: A Prospective, Randomized Trial

Authors: Patrick J. McCormick, M.D. et al Anesthesiology 12 2016, Vol.125, 1113-1120. Background: We tested the hypothesis that an electronic alert for a “double low” of mean arterial pressure less than 75 mmHg and a bispectral index less than 45 reduces the primary outcome of 90-day mortality. Methods: Adults having noncardiac surgery were randomized to receive either intraoperative […]

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Uncategorized Published - 14 November, 2016    By - Dr Clemens
Quality of Quality Measurement: Impact of Risk Adjustment, Hospital Volume, and Hospital Performance

Authors: Laurent G. Glance, M.D. et al Anesthesiology 12 2016, Vol.125, 1092-1102. Background: The validity of basing healthcare reimbursement policy on pay-for-performance is grounded in the accuracy of performance measurement. Methods: Monte Carlo simulation was used to examine the accuracy of performance profiling as a function of statistical methodology, case volume, and the extent to which hospital or […]

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Uncategorized Published - 11 November, 2016    By - Dr Clemens
Anesthesia Kills Brain Cells, but What Does It Mean?

Author: Jeffrey W. Sall, Ph.D., M.D. Commentary: Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity Anesthesiology 12 2016, Vol.125, 1090-1091. THE possibility of neurocognitive dysfunction after early exposure to anesthesia is an area of concern for anesthesiologists. Two recent clinical trials (“General Anaesthesia and Awake-Regional Anaesthesia in Infancy” [GAS] […]

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