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Uncategorized Published - 22 November, 2016    By - Dr Clemens
For TAVR, Lower Mortality Using Moderate Sedation Versus General Anesthesia

Is moderate sedation safer than general anesthesia for transcatheter aortic valve replacement (TAVR), or is it that lower-risk patients are more likely to receive moderate sedation? That is the question raised by a new 11,000-patient study that found 30-day mortality rates were 38% lower among TAVR patients who received moderate sedation than those who were […]

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Uncategorized Published - 22 November, 2016    By - Dr Clemens
Sedation and Analgesia in Pediatric Cardiac Critical Care

Authors: Viviane G. Nasr, MD et al Pediatr Crit Care Med. 2016;17(S1):S225-S231. Objectives: This review will focus on the pharmacokinetics (with an emphasis on the context-sensitive half-time), pharmacodynamics, and hemodynamic characteristics of the most commonly used sedative/hypnotic, analgesic, and IV anesthetics used in cardiac intensive care. In addition, the assessment of pain and agitation and withdrawal will […]

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Uncategorized Published - 22 November, 2016    By - Dr Clemens
Perioperative Aspirin for Prevention of Venous Thromboembolism: The PeriOperative ISchemia Evaluation-2 Trial and a Pooled Analysis of the Randomized Trials

Authors: John W. Eikelboom, M.B.B.S. et al Anesthesiology 12 2016, Vol.125, 1121-1129. Background: The PeriOperative ISchemia Evaluation-2 (POISE-2) trial compared aspirin with placebo after noncardiac surgery. Methods: The authors randomly assigned 10,010 patients undergoing noncardiac surgery to receive 200 mg aspirin or placebo 2 to 4 h before surgery and then 100 mg aspirin daily or placebo daily […]

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Uncategorized Published - 22 November, 2016    By - Dr Clemens
No Clear Right Choice for Postextubation Support

Authors: Hernández G et al., JAMA 2016 Oct 18; 316:1565 High-flow oxygen was noninferior to noninvasive positive pressure ventilation for preventing reintubation. During the last 2 years, we have seen a rapid rise in use of high-flow oxygen. Although its use is supported during the immediate postextubation period for patients at low risk for reintubation (NEJM JW […]

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Uncategorized Published - 21 November, 2016    By - Dr Clemens
Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy

Authors: Ross A. Davenport, Ph.D. et al Anesthesiology published on November 17, 2016 Background: Major trauma is a leading cause of morbidity and mortality worldwide with hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy exacerbates bleeding, but controversy remains over the degree to which inhibition of procoagulant pathways (anticoagulation), fibrinogen loss, and fibrinolysis drive the pathologic process. […]

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