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With surgery still the primary treatment for breast cancer, strategies to minimize acute postoperative pain have the potential for significant benefit, perhaps even preventing development of chronic pain. A research team at the University of California, San Francisco (UCSF) has moved much closer to this lofty goal. They developed an enhanced recovery after surgery (ERAS) […]
Read MoreAuthors: R. A. Moore et al BMC Anesthesiol. 2016;16(9) Background: Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms of action for the treatment of moderate to severe acute pain. Methods: Randomised, double-blind, parallel, placebo and active-controlled, single and multiple-dose study to evaluate the analgesic efficacy and safety of dexketoprofen/tramadol […]
Read MoreAuthors: Y. Schuller et al BMC Neurol. 2016;16(25) Background: Neuropathic pain is one of the key features of (classical) Fabry disease (FD). No randomized clinical trials comparing effectiveness of different pain management strategies have been performed. This review aims to give an overview of existing pain management strategies. Methods: PubMed and Embase were searched up to September 2014 […]
Read MoreAuthors: Walley AY and Green TC., Ann Intern Med 2016 Jun 28; Coprescribing naloxone was associated with fewer opioid-related emergency room visits. Many communities that use targeted distribution of the short-acting opioid antagonist naloxone to reverse unintentional opioid overdoses have seen declines in community-level opioid overdose–related mortality. In this observational study from six “safety net” clinics in […]
Read MoreBuprenorphine implants are at least as effective as sublingual buprenorphine as a maintenance treatment for opioid dependence, according to a noninferiority trial in JAMA. Roughly 175 adults who were clinically stable on sublingual buprenorphine were randomized to receive four buprenorphine implants plus sublingual placebo or four placebo implants plus sublingual buprenorphine. The primary endpoint — the […]
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