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Uncategorized Published - 11 May, 2017    By - Dr Clemens
Neurophysiologic Correlates of Ketamine Sedation and Anesthesia: A High-density Electroencephalography Study in Healthy Volunteers

Authors: Phillip E. Vlisides, M.D. et al Anesthesiology published on May 11, 2017. Background: Previous studies have demonstrated inconsistent neurophysiologic effects of ketamine, although discrepant findings might relate to differences in doses studied, brain regions analyzed, coadministration of other anesthetic medications, and resolution of the electroencephalograph. The objective of this study was to characterize the dose-dependent effects […]

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Uncategorized Published - 11 May, 2017    By - Dr Clemens
Validation of Innovative Techniques for Monitoring Nociception during General Anesthesia: A Clinical Study Using Tetanic and Intracutaneous Electrical Stimulation

Authors: Sandra Funcke, M.D. et al Anesthesiology published on May 11, 2017. doi:10.1097/ALN.0000000000001670 Background: This study compares the analgesic indices Analgesia Nociception Index (heart rate variability), Surgical Pleth Index (photoplethysmography), and pupillary dilatation, to heart rate, mean arterial pressure, and bispectral index, with regard to diagnostic accuracy and prediction probability for nociceptive response. The primary endpoint was […]

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Uncategorized Published - 11 May, 2017    By - Dr Clemens
Epidural Neostigmine versus Fentanyl to Decrease Bupivacaine Use in Patient-controlled Epidural Analgesia during Labor: A Randomized, Double-blind, Controlled Study

Authors: Jessica L. Booth, M.D. et al Anesthesiology published on May 11, 2017 Background: The addition of opioids to epidural local anesthetic reduces local anesthetic consumption by 20% but at the expense of side effects and time spent for regulatory compliance paperwork. Epidural neostigmine also reduces local anesthetic use. The authors hypothesized that epidural bupivacaine with neostigmine […]

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Uncategorized Published - 11 May, 2017    By - Dr Clemens
Meta-Analysis: Just a Week of NSAID Use Tied to Increased Heart Attack Risk

Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM Use of nonsteroidal anti-inflammatory drugs (NSAIDs) for even 1 week is associated with increased risk for myocardial infarction, a meta-analysis in The BMJ finds. Using individual patient data from four studies from healthcare databases, researchers identified over 61,000 cases of acute MI and 385,000 controls […]

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Uncategorized Published - 11 May, 2017    By - Dr Clemens
Perioperative Troponin Predicts 30-Day Mortality After Noncardiac Surgery

Writing Committee for the VISION Study Investigators, JAMA 2017 Apr 25; 317:1642 Most troponin elevations were not obviously symptomatic. In a 2014 study, investigators showed that even modestly elevated non–high-sensitivity troponin T levels during the 3 days after noncardiac surgery were associated independently with excess 30-day mortality (NEJM JW Gen Med Apr 1 2014 and Anesthesiology 2014; 120:564). Now, this […]

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