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In a soul-searching Emery A. Rovenstine Memorial Lecture on Monday, David Chestnut, M.D., examined the key attributes of professionalism and his own journey on the road to professionalism in anesthesiology. “Each of us helps shape the culture of professionalism in our practice environment. Professionalism is not something that we learn once. None of us is […]
Read MoreDavid J. Bjorkman, MD, MSPH (HSA), SM (Epid.) Reviewing Kumar NL et al., Gastrointest Endosc 2016 Sep 29; Earlier endoscopy — performed within 12 versus 24 hours of bleeding presentation — was associated with worse outcomes in low-risk patients. Most guidelines recommend that patients with nonvariceal upper gastrointestinal bleeding (UGIB) undergo endoscopy within 24 hours of presentation. But […]
Read MoreEdited by Susan Sadoughi, MD, and André Sofair, MD, MPH Elective sigmoidectomy is associated with improved quality of life for patients with recurrent and persistent symptoms after a diverticulitis episode, suggests an open-label trial in the Lancet Gastroenterology & Hepatology. Roughly 100 Dutch patients who’d had an episode of left-sided diverticulitis followed by either ongoing abdominal complaints lasting […]
Read MoreAuthors: Colin F. Royse, M.B.B.S., M.D., F.A.N.Z.C.A. et al Anesthesiology published on October 23, 2016 Background: Inflammation after cardiopulmonary bypass may contribute to postoperative delirium and cognitive dysfunction. The authors evaluated the effect of high-dose methylprednisolone to suppress inflammation on the incidence of delirium and postoperative quality of recovery after cardiac surgery. Methods: Five hundred fifty-five adults from […]
Read MoreAuthors: Lesley K. Rao, M.D. et al Anesthesiology published on October 23, 2016. Background: At therapeutic concentrations, cytochrome P4502B6 (CYP2B6) is the major P450 isoform catalyzing hepatic ketamine N-demethylation to norketamine in vitro. The CYP2B6 gene is highly polymorphic. The most common variant allele, CYP2B6*6, is associated with diminished hepatic CYP2B6 expression and catalytic activity compared with wild-type CYP2B6*1/*1. CYP2B6.6, […]
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