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Authors: Åse Lodenius, M.D., D.E.S.A.et al Anesthesiology 10 2016, Vol.125, 700-715 Background: In contrast to general anesthetics such as propofol, dexmedetomidine when used for sedation has been put forward as a drug with minimal effects on respiration. To obtain a more comprehensive understanding of the regulation of breathing during sedation with dexmedetomidine, the authors compared ventilatory responses […]
Read MoreOpioids are widely used in the United States to manage moderate to severe acute postoperative pain, but adverse events, including respiratory depression and gastrointestinal dysfunction, can limit the dosing required for analgesic efficacy. Oliceridine—a novel mu-receptor G protein pathway selective modulator—may provide effective, rapid analgesia and reduce typical adverse effects, according to two recent Phase […]
Read MoreAnesthesia & Analgesia: October 2016 – Volume 123 – Issue 4 – p 836–843 Authors: Sivanesan, Eellan MD et al Despite their association with multiple adverse effects, opioid prescription continues to increase. Opioid-induced hallucination is an uncommon yet significant adverse effect of opioid treatment. The practitioner may encounter patient reluctance to volunteer the occurrence of […]
Read MoreAuthors: Donna M. Urquhart et al Background Low back pain is a major clinical and public health problem, with limited evidence-based treatments. Low-dose antidepressants are commonly used to treat pain in chronic low back pain. However, their efficacy is unproven. The aim of this pragmatic, double-blind, randomised, placebo-controlled trial is to determine whether low-dose amitriptyline […]
Read MoreChildren, toddlers flood hospital emergency rooms due to opioid poisoning, study finds The research underscores the need for doctors to talk to patients about ways to keep the drugs safely, especially if children are in the household. Kaiser Health News As the nation continues to confront an epidemic of opioid and prescription painkiller addiction and […]
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