The FDA has approved abaloparatide (marketed as Tymlos) for the treatment of postmenopausal women with osteoporosis who are at high risk for fracture — that is, those who have had a prior osteoporotic fracture, have multiple fracture risk factors, or have failed or cannot tolerate other osteoporosis therapies. The osteoanabolic agent is a synthetic analog […]
Read MoreEdited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM Spinal manipulation improves pain and function in adults with acute low back pain, although the effects are “clinically modest,” according to the authors of a JAMA meta-analysis. The analysis included 26 randomized controlled trials comparing spinal manipulation with sham or alternative treatments (e.g., physical therapy) […]
Read MoreAuthors: Abdullah Sulieman Terkawi, M.D. et al Anesthesiology 5 2017, Vol.126, 923-937 Background: Optimal analgesia for total knee arthroplasty remains challenging. Many modalities have been used, including peripheral nerve block, periarticular infiltration, and epidural analgesia. However, the relative efficacy of various modalities remains unknown. The authors aimed to quantify and rank order the efficacy of available analgesic […]
Read MoreAuthors: Alexander Zarbock, M.D. et Anesthesiology 5 2017, Vol.126, 787-798. Background: In a multicenter, randomized trial, the authors enrolled patients at high-risk for acute kidney injury as identified by a Cleveland Clinic Foundation score of 6 or more. The authors enrolled 240 patients at four hospitals and randomized them to remote ischemic preconditioning or control. The authors […]
Read MoreAuthor: David H. Chestnut, M.D. Anesthesiology 5 2017, Vol.126, 780-786 Many observers have concluded that we have a crisis of professionalism in the practice of medicine. In this essay, the author identifies and discusses personal attributes and commitments important in the development and maintenance of physician professionalism: humility, servant leadership, self-awareness, kindness, altruism, attention to personal […]
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