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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Extubation Failure in Brain-injured Patients: Risk Factors and Development of a Prediction Score in a Preliminary Prospective Cohort Study

Authors: Thomas Godet, M.D., Ph.D. et al Anesthesiology 1 2017, Vol.126, 104-114. Background: The decision to extubate brain-injured patients with residual impaired consciousness holds a high degree of uncertainty of success. The authors developed a pragmatic clinical score predictive of extubation failure in brain-injured patients. Methods: One hundred and forty brain-injured patients were prospectively included after the first […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury

Authors: Jukka Kortelainen, M.D., Ph.D. et al Anesthesiology 1 2017, Vol.126, 94-103. Background: Slow waves (less than 1 Hz) are the most important electroencephalogram signatures of nonrapid eye movement sleep. While considered to have a substantial importance in, for example, providing conditions for single-cell rest and preventing long-term neural damage, a disturbance in this neurophysiologic phenomenon is […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Vasopressin versusNorepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial

Authors: Ludhmila Abrahao Hajjar, M.D., Ph.D. et al      Anesthesiology 1 2017, Vol.126, 85-93. Background: Vasoplegic syndrome is a common complication after cardiac surgery and impacts negatively on patient outcomes. The objective of this study was to evaluate whether vasopressin is superior to norepinephrine in reducing postoperative complications in patients with vasoplegic syndrome. Methods: This prospective, randomized, double-blind […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Relationship between Intraoperative Hypotension, Defined by Either Reduction from Baseline or Absolute Thresholds, and Acute Kidney and Myocardial Injury after Noncardiac Surgery: A Retrospective Cohort Analysis

Authors: Vafi Salmasi, M.D. et al       Anesthesiology 1 2017, Vol.126, 47-65  Background: How best to characterize intraoperative hypotension remains unclear. Thus, the authors assessed the relationship between myocardial and kidney injury and intraoperative absolute (mean arterial pressure [MAP]) and relative (reduction from preoperative pressure) MAP thresholds. Methods: The authors characterized hypotension by the lowest MAP below various […]

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Uncategorized Published - 21 December, 2016    By - Dr Clemens
Rapid Occurrence of Chronic Kidney Disease in Patients Experiencing Reversible Acute Kidney Injury after Cardiac Surgery

Authors: David Legouis, M.D. et al     Anesthesiology 1 2017, Vol.126, 39-46. Background: There is recent evidence to show that patients suffering from acute kidney injury are at increased risk of developing chronic kidney disease despite the fact that surviving tubular epithelial cells have the capacity to fully regenerate renal tubules and restore renal function within days […]

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