Authors: Andrew J. Toner, F.R.C.A. et al Anesthesiology published on December 8, 2016. Background: Glucocorticoids are increasingly used perioperatively, principally to prevent nausea and vomiting. Safety concerns focus on the potential for hyperglycemia and increased infection. The authors hypothesized that glucocorticoids predispose to such adverse outcomes in a dose-dependent fashion after elective noncardiac surgery. Methods: The authors […]
Read MoreAuthors: Lukas Lannemyr, M.D. et al Anesthesiology published on December 8, 2016. Background: Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass. The authors evaluated the effects of normothermic cardiopulmonary bypass on renal blood flow, glomerular filtration rate, renal oxygen consumption, and renal oxygen supply/demand relationship, i.e., renal oxygenation (primary outcome) in […]
Read MoreAuthors: Michael R. Mathis, M.D. et al Anesthesiology published on December 8, 2016 Background: Assessment of need for intravascular volume resuscitation remains challenging for anesthesiologists. Dynamic waveform indices, including systolic and pulse pressure variation, are demonstrated as reliable measures of fluid responsiveness for mechanically ventilated patients. Despite widespread use, real-world reference distributions for systolic and pulse […]
Read MoreAuthors: Matthieu Biais, M.D., Ph.D. et al Anesthesiology published on December 8, 2016. Background: Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Methods: Twenty-eight mechanically ventilated patients with low tidal volume […]
Read MoreAuthors: Tong J. Gan, M.D. et al Anesthesiology published on December 8, 2016. Background: Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. Methods: Adult inpatients undergoing elective surgery during general anesthesia and having at […]
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