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BJA: British Journal of Anaesthesia · February 10, 2017 Background: Predictive performance of eleven published propofol pharmacokinetic models was evaluated for long-duration propofol infusion in children. Methods: Twenty-one aged three–11 yr ASA I–II patients were included. Anaesthesia was induced with propofol or sevoflurane, and maintained with propofol, remifentanil, and fentanyl. Propofol was continuously infused at rates of 4–14 mg […]
Read MoreWhen it comes to mitigating against postoperative cognitive decline and preserving functional brain connectivity after circulatory arrest for aortic arch surgery, deep hypothermia is superior to high-moderate hypothermia, a pilot study has concluded. A larger prospective trial is underway to confirm these results. “Deep hypothermia—which constitutes cooling the body to a temperature of less than […]
Read MoreAuthors: Kawazoe Y et al., JAMA 2017 Apr 4; 317:1321 Patients with sepsis had similar outcomes when sedated with or without dexmedetomidine. Multiple recent trials have yielded mixed results on whether dexmedetomidine for sedation during mechanical ventilation prevents delirium. Interestingly, however, one such study suggested markedly lower mortality in septic patients who were sedated with dexmedetomidine (Crit Care […]
Read MoreAlthough a restrictive transfusion strategy significantly reduces the risk for 30-day all-cause mortality in critical care patients, its benefits are less clear in perioperative patients, according to a meta-analysis by a Canadian research team. “Although packed red blood cells are arguably the best therapy to use when you have a problem with oxygen-carrying capacity, they […]
Read MoreAlthough epidural anesthesia is considered the gold standard for postthoracotomy pain treatment, it is contraindicated in certain patients.Although epidural anesthesia is considered the gold standard for postthoracotomy pain treatment, it is contraindicated in certain patients. According to a retrospective study by researchers at the Shizuoka Cancer Center in Japan, continuous thoracic paravertebral nerve block (PVB) […]
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