Authors: Rutger van der Schrier, M.D. et al Anesthesiology 3 2017, Vol.126, 534-542. Background: Respiratory depression is a potentially fatal complication of opioid use, which may be exacerbated by simultaneous ethanol intake. In this three-way sequential crossover dose-escalating study, the influence of coadministration of oral oxycodone and intravenous ethanol was assessed on resting ventilation, apneic events and […]
Read MoreAuthors: Fabienne M. A. van Hout, M.D. et al Anesthesiology 3 2017, Vol.126, 441-449. Background: Conflicting results have been reported concerning the effect of platelet transfusion on several outcomes. The aim of this study was to assess the independent effect of a single early intraoperative platelet transfusion on bleeding and adverse outcomes in cardiac surgery patients. Methods: For […]
Read MoreAuthors: Robert D. Sanders, M.B.B.S., Ph.D., F.R.C.A. et al Anesthesiology 2 2017, Vol.126, 214-222. Background: The isolated forearm technique allows assessment of consciousness of the external world (connected consciousness) through a verbal command to move the hand (of a tourniquet-isolated arm) during intended general anesthesia. Previous isolated forearm technique data suggest that the incidence of connected consciousness […]
Read MoreAuthors: Lukas Lannemyr, M.D. et al Anesthesiology 2 2017, Vol.126, 205-213. Background: Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass. The authors evaluated the effects of normothermic cardiopulmonary bypass on renal blood flow, glomerular filtration rate, renal oxygen consumption, and renal oxygen supply/demand relationship, i.e., renal oxygenation (primary outcome) in patients undergoing cardiac […]
Read MoreAuthors: Mathieu Raux, M.D., Ph.D. et al Anesthesiology 3 2017, Vol.126, 522-533. Background: Initial blood lactate and base deficit have been shown to be prognostic biomarkers in trauma, but their respective performances have not been compared. Methods: Blood lactate levels and base deficit were measured at admission in trauma patients in three level 1 trauma centers. This […]
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