Injectable extended-release naltrexone (Vivitrol) appears to be as safe and effective as daily oral buprenorphine-naloxone for treating opioid dependence, according to a Norway-based, noninferiority trial in JAMA Psychiatry. Roughly 160 opioid-dependent adults who were discharged from addiction treatment programs were randomized to receive either oral buprenorphine-naloxone daily or extended-release intramuscular naltrexone every 4 weeks for 12 […]
Read MoreDaniel J. Pallin, MD, MPH reviewing Vinson DR et al. Ann Emerg Med 2017 Sep 29. Ibutilide successfully cardioverted 55% of patients within 4 hours in a multicenter retrospective cohort study. Ibutilide is a class III antiarrhythmic drug that is effective for cardioverting atrial fibrillation or flutter (AF/F). However, reported rates of induced ventricular tachycardia of around 1% may […]
Read MoreAuthors: Robert I. Block, Ph.D. et al Anesthesiology 11 2017, Vol.127, 788-799. Background: Anesthetics have neurotoxic effects in neonatal animals. Relevant human evidence is limited. We sought such evidence in a structural neuroimaging study. Methods: Two groups of children underwent structural magnetic resonance imaging: patients who, during infancy, had one of four operations commonly performed in otherwise healthy […]
Read MoreResearchers assessed more than 35,000 patients in an effort to tease out a clearer understanding of the association between gastroesophageal reflux disease and fibromyalgia. Interviews with Don Goldenberg, MD, and Michael R. Clark, MD, MPH, MBA Fibromyalgia (FM) and gastroesophageal reflux disease (GERD) appear to arise frequently in the same patient, an interrelationship that has […]
Read MoreAuthor: Robert M. Knapp, D.O., J.D. Anesthesiology 11 2017, Vol.127, 904-905. To the Editor: The editorial by Garcia and Sleigh1 provided an outstanding discussion of ketamine’s complexities. Their conclusion, that we use a flawed concept of anesthesia depth, was insightful and provides a reason as well as an opportunity to suggest something more meaningful. Anesthetic “depth” is […]
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