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Uncategorized Published - 14 January, 2019    By - Dr Clemens
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

Authors: De Gregorio, Danilo et al PAIN: January 2019 – Volume 160 – Issue 1 – p 136–150 Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. However, its effects on 5-HT neuronal activity, as well as its impact on models of neuropathic pain are […]

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Uncategorized Published - 14 January, 2019    By - Dr Clemens
INTRANASAL KETAMINE AS EFFECTIVE AS FENTANYL AT RELIEVING ACUTE PAIN IN KIDS

Author: Will Boggs MD JAMA Pediatr  Dec 28 2018. Intranasal ketamine is noninferior to intranasal fentanyl at relieving pain in children with acute extremity injuries, a new study found. “We were happy to discover similar results to the two other prior pediatric trials and pleasantly surprised to see how similar the rates of rescue analgesia were […]

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Uncategorized Published - 14 January, 2019    By - Dr Clemens
Infection prevention in the operating room anesthesia work area

aUTJOHRS: Munoz-Price LS, et al. Infection Control & Hospital Epidemiology 2019, 40, 1–17. Purpose The potential for clinically significant microbial cross transmission in the intraoperative environment poses a threat to patient safety. A growing body of literature has shown contamination in the anesthesia work area, including the anesthesia medical work cart, stopcocks, laryngeal masks and laryngoscope blades, […]

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Uncategorized Published - 14 January, 2019    By - Dr Clemens
Medical Marketing in the United States, 1997-2016

Authors: Lisa M. Schwartz, MD, MS et al  JAMA. 2019;321(1):80-96. Key Points Question  How has the marketing of prescription drugs, disease awareness, health services, and laboratory tests in the United States changed from 1997 through 2016? Findings  From 1997 through 2016, medical marketing expanded substantially, and spending increased from $17.7 to $29.9 billion, with direct-to-consumer advertising for prescription drugs and […]

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Uncategorized Published - 14 January, 2019    By - Dr Clemens
Should Drug Testing Be Implemented Before Prescribing Opioids and Benzodiazepines?

Clinicians should get their patients tested for drugs before prescribing them opioid or benzodiazepine medications—and on a regular basis when patients are on those drugs—as drug-drug interactions may be associated with risks, according to a study presented during the 2018 PAINWeek conference. “Opioid-related morbidity and mortality are well recognized issues in the United States, but unlike opioid prescribing, […]

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