AUTHORS: Saengsin, Kwannapas MD et al Anesthesia & Analgesia 137(5):p 1056-1065, November 2023. BACKGROUND: Phosphodiesterase inhibitors are known to relieve symptoms in the setting of heart failure, although their effects in restrictive ventricular physiology have been poorly characterized. We explored the association between the use of milrinone and volume administration during the first 72 hours following […]
Arterial Hyperoxemia During Cardiopulmonary Bypass Was Not Associated With Worse Postoperative Pulmonary Function
AUITHORS: Kelava, Marta MD, MS et al Anesthesia & Analgesia 138(5):p 1003-1010, May 2024 BACKGROUND: Arterial hyperoxemia may cause end-organ damage secondary to the increased formation of free oxygen radicals. The clinical evidence on postoperative lung toxicity from arterial hyperoxemia during cardiopulmonary bypass (CPB) is scarce, and the effect of arterial partial pressure of oxygen (Pao2) […]
Postanesthesia Care Unit Recovery Time According to Volatile Anesthetic Used in Clinical Practice
AUTHORS: Sprung, Juraj MD, PhD et al Anesthesia & Analgesia 137(5):p 1066-1074, November 2023. BACKGROUND: Whether volatile anesthetic solubility affects postanesthesia recovery time in clinical practice is unclear. We investigated the association among 3 volatile agents and 2 clinically relevant outcomes—postanesthesia care unit (PACU) recovery time (time from PACU admission to fulfillment of discharge criteria) and […]
Gain Changers: New Generation of Weight Loss Medications
Authors: Dibash Kumar Das, PhD; Steven Shafer, MD, FASA ASA Monitor September 2023, Vol. 87, 1–4. Hosting the 95th Academy Awards, Jimmy Kimmel opened his monologue by saying, “Everybody looks so great! When I look around this room, I can’t help but wonder, ‘Is Ozempic right for me?’” Semaglutide (Ozempic, Wegovy, and Rybelsus) is blowing up social media […]
Virtual Reality Distraction for Reducing Acute Postoperative Pain After Hip Arthroplasty
AUTHORS: Araujo-Duran, Jorge MD Anesthesia & Analgesia 138(4):p 751-759, April 2024. | BACKGROUND: Relaxation and distraction provided by virtual reality presentations might be analgesic and reduce the need for opioid analgesia. We tested the hypothesis that a virtual reality program (AppliedVR) decreases acute postoperative pain and opioid requirements in patients recovering from hip arthroplasty. We also evaluated […]
Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery
Authors: Michael R. Mathis, M.D. et al Anesthesiology August 2023, Vol. 139, 122–141. Background Conflicting evidence exists regarding the risks and benefits of inotropic therapies during cardiac surgery, and the extent of variation in clinical practice remains understudied. Therefore, the authors sought to quantify patient-, anesthesiologist-, and hospital-related contributions to variation in inotrope use. Methods In […]
Sex-Specific Associations Between Preoperative Hemoglobin and Outcomes After Major Noncardiac Surgery
AUTHORS: Zhao, Bing-Cheng MD et al Anesthesia & Analgesia 137(5):p 1019-1028, November 2023. BACKGROUND: Preoperative anemia is an established risk factor for morbidity and mortality after surgery. Men and women have different hemoglobin concentrations and are at different risks of postoperative complications. However, sex-stratified analysis on the association between preoperative hemoglobin and outcomes after noncardiac surgery […]
Inflammatory pain affects alcohol intake in a dose-dependent manner in male rats in the intermittent access model
Authors: Campos-Jurado et al PAIN Reports 8(4):p e1082, July/August 2023. Introduction: Epidemiological studies have shown that there is a relation between pain and alcohol use disorder (AUD). Persistent pain is directly correlated with an increment in alcohol consumption and an increased risk of developing an AUD. Greater levels of pain intensity and unpleasantness are associated with […]
Hyperoxia Increases Kidney Injury During Renal Ischemia and Reperfusion in Mice
AUTHORS: Kimlinger, Melissa J. BS et al Anesthesia & Analgesia 137(5):p 996-1006, November 2023. BACKGROUND: Renal ischemia and reperfusion (IR) contribute to perioperative acute kidney injury, and oxygen is a key regulator of this process. We hypothesized that oxygen administration during surgery and renal IR would impact postoperative kidney function and injury in mice. METHODS: Mice […]
Does Anesthesia Quality Improvement Participation Lead to Incremental Savings in a Surgical Quality Collaborative Population?
AUTHORS: Janda, Allison M. MD et al Anesthesia & Analgesia 137(5):p 1093-1103, November 2023. BACKGROUND: The Anesthesiology Performance Improvement and Reporting Exchange (ASPIRE) Collaborative Quality Initiative (CQI) was launched as a partnership among hospitals to measure quality, review evidence-based practices, and improve anesthesia-related outcomes. Cost savings and improved patient outcomes have been associated with surgical CQI […]