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AUTHORS: Holmgaard, Frederik BMSc et al Anesthesia & Analgesia: June 2019 – Volume 128 – Issue 6 – p 1081-1088 BACKGROUND: Near-infrared spectroscopy (NIRS) is used worldwide to monitor regional cerebral oxygenation (rScO2) during cardiopulmonary bypass (CPB). Intervention protocols meant to mitigate cerebral desaturation advocate to increase mean arterial pressure (MAP) when cerebral desaturation occurs. However, […]
Read MoreAuthors: Molero Y et al. BMJ 2019 Jun 12 Multiple adverse behavioral and psychomotor associations are found with these drugs although the effects might be confined to pregabalin. Clinicians often prescribe gabapentin and pregabalin for pain, sleep, and anxiety symptoms, and some view these drugs as safe alternatives to benzodiazepines and opioids in, for example, patients […]
Read MoreAUTHORS: Benzon, Honorio T. MD et al Anesthesia & Analgesia: June 2019 – Volume 128 – Issue 6 – p 1089-1096 BACKGROUND: Patients presenting for surgery may have isolated or combined prolonged activated partial thromboplastin time (aPTT) and/or prothrombin time (PT). In patients not receiving anticoagulants or with no identifiable cause for abnormal clot formation, a […]
Read MoreI thought this was interesting so I wanted to share it with our readers. By Mark Terry BioSpace In 1992, the U.S. Food and Drug Administration (FDA) developed its Accelerated Approval Program. It was designed to move certain new drugs to the market faster. The Accelerated Approval leans on a surrogate endpoint, which is a marker, such as […]
Read MoreAuthor: Tauren Dyson People with osteoarthritis who take NSAIDs have a 23 percent higher likelihood of developing cardiac disease compared to people without the condition. File Photo by Kzenon/Shutterstock Nonsteroidal anti-inflammatory drugs that treat inflammation and pain raise the risk of congenital heart disease, heart attack and other conditions for people with osteoarthritis, new findings […]
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