Authors: Kong, Hao et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005778 This randomized, double-blind, placebo-controlled trial assessed whether preemptive magnesium sulfate infusion can improve intraoperative hemodynamic stability in patients undergoing pheochromocytoma or paraganglioma (PPGL) resection—procedures known for extreme fluctuations in blood pressure and heart rate due to catecholamine release. Ninety-two patients scheduled for PPGL surgery […]
Read MoreAuthors: Kjaerulff, Isabella et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005780 This prospective mixed-methods study explored the relationship between preoperative psychological distress and postoperative outcomes in older adults undergoing noncardiac, nonneurosurgical procedures. Despite growing recognition that emotional well-being influences recovery, routine distress screening has not yet been integrated into most preoperative assessments. A total of […]
Read MoreAuthors: Persson, Niklas Daniel Åke et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005794 This preclinical imaging study investigated how anesthesia type and systemic hyperosmolality affect the central nervous system (CNS) distribution of intrathecally administered drugs. The researchers examined the pharmacokinetics of a high–molecular weight spinal tracer (technetium-99m–labeled human serum albumin nanocolloid, 66.5 kDa) in female […]
Read MoreEdited by Melissa Warburg Medscape A recent phase 3 study of more than 800 adults, published in Nature, revealed encouraging results for a cannabis extract in treating chronic low back pain, offering new hope for patients seeking nonopioid relief. VER-01, a full-spectrum Cannabis sativa extract, provided sustained pain reduction while also improving sleep quality and physical function, and without requiring […]
Read MoreAuthors: Langer, Sarah et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005785 This meta-analysis of randomized controlled trials compared neonatal outcomes following cesarean delivery performed under regional anesthesia (spinal, epidural, or combined spinal-epidural) versus general anesthesia. Although regional techniques are widely preferred for maternal safety and recovery, their comparative effect on neonatal well-being has remained uncertain. […]
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