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apsf The unanticipated increased use of propofol as a sedative for ventilated patients has strained the nation’s propofol supply for intensive care units. As a result, the FDA has issued an Emergency Use Authorization (EUA) for emergency use of the Fresenius Kabi Propoven 2% Emulsion to maintain sedation via continuous infusion in patients 16 years and older who require […]
Read MoreAUTHORS: Mascha, Edward J. PhD et al Anesthesia & Analgesia: April 2020 Purpose: Healthcare worker (HCW) safety is of pivotal importance during a pandemic such as Coronavirus Disease 2019 (COVID-19), and employee health and well-being ensures functionality of healthcare institutions. This is particularly true for an intensive care unit (ICU) where highly specialized staff cannot be readily […]
Read MoreNEJM Journal Watch By Kelly Young Edited by Jaye Elizabeth Hefner, MD Preliminary results regarding the use of remdesivir against novel coronavirus disease (COVID-19) have been updated and published in the New England Journal of Medicine. (An earlier accounting, which we also reported here, led to the drug’s emergency approval by the FDA.) Over 1000 hospitalized patients […]
Read MoreAUTHORS: Zhang, Pengcheng MD et al Anesthesia & Analgesia: April 2020 – Volume 130 – Issue 4 – p 879-889 BACKGROUND: Whether intraoperative positive end-expiratory pressure (PEEP) can reduce the risk of postoperative pulmonary complications remains controversial. We performed a systematic review of currently available literature to investigate whether intraoperative PEEP decreases pulmonary complications in […]
Read MoreAUTHORS: Eley, Victoria A. PhD et al Anesthesia & Analgesia: April 2020 BACKGROUND: Obesity is a risk factor for surgical site infection after cesarean delivery. There is inadequate pharmacokinetic data available regarding prophylactic cefazolin dosing in obese pregnant women. We aimed to describe the plasma and interstitial fluid (ISF) pharmacokinetics of cefazolin in obese women […]
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