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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Association Between Intraoperative Remifentanil Dosage and Postoperative Opioid Consumption in Adolescent Idiopathic Spine Surgery

AUTHORS: Lo, Calvin MD, MSc et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 984-990 BACKGROUND:  Adolescent idiopathic scoliosis (AIS) surgery is associated with significant postoperative pain. Remifentanil is a short-acting opioid that is often used as a component of total intravenous anesthesia. Remifentanil has been implicated in acute opioid […]

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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Quantitative Pupillometry as a Predictor of Pediatric Postoperative Opioid–Induced Respiratory Depression

AUTHORS: Packiasabapathy, Senthil MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 991-999 BACKGROUND:  Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification […]

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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Effect of Permissive Mild Hypercapnia on Cerebral Vasoreactivity in Infants

AUTHORS: Schopfer, Leonore MMSc et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 976-983 BACKGROUND:  Mechanical ventilation interferes with cerebral perfusion via changes in intrathoracic pressure and/or as a consequence of alterations in CO2. Cerebral vascular vasoreactivity is dependent on CO2, and hypocapnia can potentially lead to vasoconstriction and subsequent […]

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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Hemodynamic and Intestinal Microcirculatory Changes in a Phenylephrine Corrected Porcine Model of Hemorrhage

AUTHORS: Davies, Simon J. MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1060-1069 BACKGROUND:  Intraoperative hypotension is a common event, and a recent study suggests that maintenance of blood pressure may reduce complications. The splanchnic circulation provides a reservoir of blood that can be mobilized during hemorrhage; hence, […]

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Uncategorized Published - 18 October, 2021    By - Dr Clemens
Association Between Hyperbaric Bupivacaine Dose and Maternal Hypotension: Retrospective Database Study of 8226 Women Undergoing Cesarean Delivery Under Spinal Anesthesia

AUTHORS: Weiniger, Carolyn F. MB, ChB et al    Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 967-975 BACKGROUND:  Low-dose (≤8 mg) hyperbaric bupivacaine for spinal anesthesia during cesarean delivery results in reduced efficacy, yet as a secondary outcome was associated with reduced frequency of spinal-induced hypotension. Our primary aim was […]

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