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Uncategorized Published - 16 December, 2021    By - Dr Clemens
Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Authors: Ricardo Alvarez-Jimenez, M.D., Ph.D. et al  Anesthesiology December 2021. Background Numerous pharmacokinetic models have been published aiming at more accurate and safer dosing of dexmedetomidine. The vast majority of the developed models underpredict the measured plasma concentrations with respect to the target concentration, especially at plasma concentrations higher than those used in the original […]

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Uncategorized Published - 16 December, 2021    By - Dr Clemens
Effect of high-flow oxygen therapy vs conventional oxygen therapy on invasive mechanical ventilation and clinical recovery in patients with severe COVID-19

DG Alerts Among patients with severe coronavirus disease 2019 (COVID-19), use of high-flow oxygen through a nasal cannula significantly decreased need for mechanical ventilation support and time to clinical recovery compared with conventional low-flow oxygen therapy, according to a study published in JAMA. From August 2020 to January 2021, 220 patients with respiratory distress and a […]

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Uncategorized Published - 15 December, 2021    By - Dr Clemens
Preoperative Point-of-Care Ultrasound to Identify Frailty and Predict Postoperative Outcomes

Authors: Cecilia Canales, M.D., M.P.H. et al  Anesthesiology December 2021. Background Frailty is increasingly being recognized as a public health issue, straining healthcare resources and increasing costs to care for these patients. Frailty is the decline in physical and cognitive reserves leading to increased vulnerability to stressors such as surgery or disease states. The goal […]

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Uncategorized Published - 15 December, 2021    By - Dr Clemens
Coffee Is Not a Clear Liquid

Authors: Pandit, Sujit K. MD; Loberg, Katherine W. BS; Pandit, Uma A. MD Anesthesia & Analgesia: November 2000 – Volume 91 – Issue 5 – p 1308 This also gives us an opportunity to clarify the prevalent ambiguity about types of “clear” liquid that are allowed 2–3 h before elective surgery. Dr. Sosis has asked a […]

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Uncategorized Published - 15 December, 2021    By - Dr Clemens
Neuromuscular Blockade and Reversal Practice Variability in the Outpatient Setting

AUTHORS: Bash, Lori D. PhD, MPH et al  Anesthesia & Analgesia: December 2021 – Volume 133 – Issue 6 – p 1437-1450 BACKGROUND:  Neuromuscular blockade (NMB) is a critical part of many surgical procedures. Data on practice patterns of NMB agents (NMBAs) and NMB reversal in recent years in the US ambulatory surgical care setting are […]

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