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Uncategorized Published - 9 June, 2022    By - Dr Clemens
Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice Via Canonical Nitric Oxide Mediated Protein Kinase-G Signaling

Authors: Swati Agarwal, Ph.D. et al  Anesthesiology May 2022. Background Inhalational anesthetics are known to disrupt PDZ2 domain-mediated protein-protein interactions of the postsynaptic density (PSD)-95 protein. The aim of this study is to investigate the underlying mechanisms in response to early isoflurane exposure on synaptic PSD-95 PDZ2 domain disruption that altered spine densities and cognitive […]

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Uncategorized Published - 9 June, 2022    By - Dr Clemens
Expert Consensus Regarding Core Outcomes for Enhanced Recovery after Cesarean Delivery Studies

Authors: Pervez Sultan, M.B.Ch.B. et al  Anesthesiology Newly Published on June 2022. Background Heterogeneity among reported outcomes from enhanced recovery after cesarean delivery impact studies is high. This study aimed to develop a standardized enhanced recovery core outcome set for use in future enhanced recovery after cesarean delivery studies. Methods An international consensus study involving physicians, […]

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Uncategorized Published - 9 June, 2022    By - Dr Clemens
Early Restrictive Fluid Strategy Impairs the Diaphragm Force in Lambs with Acute Respiratory Distress Syndrome

Authors: Marloes M. Ijland, M.D. et al  Anesthesiology May 2022, Vol. 136, 749–762. Background The effect of fluid management strategies in critical illness–associated diaphragm weakness are unknown. This study hypothesized that a liberal fluid strategy induces diaphragm muscle fiber edema, leading to reduction in diaphragmatic force generation in the early phase of experimental pediatric acute respiratory […]

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Uncategorized Published - 9 June, 2022    By - Dr Clemens
Ketamine Psychedelic and Antinociceptive Effects Are Connected

Authors: Erik Olofsen, Ph.D. et al  Anesthesiology May 2022, Vol. 136, 792–801. Background Ketamine produces potent analgesia combined with psychedelic effects. It has been suggested that these two effects are associated and possibly that analgesia is generated by ketamine-induced dissociation. The authors performed a post hoc analysis of previously published data to quantify the pharmacodynamic properties of ketamine-induced […]

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Uncategorized Published - 8 June, 2022    By - Dr Clemens
Stuck in a Rut: Anesthetic Brain Dynamics in the Young

Author: Jamie W. Sleigh, M.D. Anesthesiology July 2022, Vol. 137, 4–5. “General anesthesia had rendered the brains of the young patients functionally ‘rigid,’ [which] contrasts with a previous study in adults.” Every human would agree that wakefulness is marked by a succession of experiences—the “stream-of-consciousness.” This implies that the state of the brain is continuously changing […]

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