Month: December 2024

Uncategorized Published - 6 December, 2024    By - Dr Clemens
Activation of α7 Nicotinic Acetylcholine Receptors Inhibits Hepatic Necroptosis and Ameliorates Acute Liver Injury in Mice

Authors: Fang-Fang Xu, M.S. et al  Anesthesiology December 2024, Vol. 141, 1119–1138. Background Acute liver injury is a disease characterized by severe liver dysfunction, caused by significant infiltration of immune cells and extensive cell death with a high mortality. Previous studies demonstrated that the α7 nicotinic acetylcholine receptor (α7nAChR) played a crucial role in various liver […]

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Uncategorized Published - 6 December, 2024    By - Dr Clemens
Science, Medicine, and the Anesthesiologist

Author: Martin J. London, M.D Anesthesiology December 2024, Vol. 141, A13–A15. Intraoperative oxygen treatment, oxidative stress, and organ injury following cardiac surgery: A randomized clinical trial. JAMA Surg 2024; 159:1106–16. PMID: 39110454. Liberal administration of oxygen (hyperoxia) is commonly used intraoperatively ostensibly to enhance patient safety, particularly during cardiac surgery, despite potential adverse effects on perioperative […]

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Uncategorized Published - 5 December, 2024    By - Dr Clemens
Intraoperative Vasopressors and Delirium: Reply

Authors: Haobo Ma, M.D., M.Sc., M.P.H. et al  Anesthesiology December 2024, Vol. 141, 1211–1212. In Reply: We thank Drs. Kumar and Jain1  for their interest in our study on the association between intraoperative use of phenylephrine, compared to ephedrine, and delirium after noncardiac surgery under general anesthesia. We appreciate the authors’ remarks emphasizing the importance of our […]

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Uncategorized Published - 5 December, 2024    By - Dr Clemens
Intraoperative Vasopressors and Delirium: Comment

Authors: Ashish Kumar, M.D.; Amit Jain, M.D. Anesthesiology December 2024, Vol. 141, 1209–1210. To the Editor: We read with a great interest the multicenter retrospective cohort study by Ma et al.  demonstrating higher odds of developing postoperative delirium with phenylephrine use in comparison to ephedrine for the management of intraoperative hypotension. Additionally, a dose-dependent effect of phenylephrine on the […]

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Uncategorized Published - 5 December, 2024    By - Dr Clemens
Comparing the Hypotension Prediction Index to Mean Arterial Pressure and Linear Extrapolated Mean Arterial Pressure for the Prediction of Intraoperative Hypotension

Authors: Dario Massari, M.D. et al  Anesthesiology December 2024, Vol. 141, 1200–1202. To the Editor: Criticism regarding the predictive abilities of the Hypotension Prediction Index software has recently emerged1  and it was suggested that the performance of Hypotension Prediction Index software should be compared to that of linearly extrapolated mean arterial pressure (MAP) and single MAP values.  Moreover, […]

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Uncategorized Published - 5 December, 2024    By - Dr Clemens
Discover The Best Anesthesiologist Opportunity in New Mexico

We are seeking a dedicated anesthesiologist to join our all-anesthesiologist group. Our team will consist of 4 full-time providers and 1 for vacation relief, managing 3 operating rooms. Position Highlights: Zero call for 3 weeks, followed by 1 week of call without daytime work only call after 7 PM therefore you may not work the […]

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Uncategorized Published - 5 December, 2024    By - Dr Clemens
Ex Utero Intrapartum Intubation for Giant Fetal Neck Mass

Authors: Mengyun Zhao, M.D. et al  Anesthesiology December 2024, Vol. 141, 1139–1140. Giant fetal neck masses are congenital anomalies that pose significant perinatal risks, including mortality, hypoxia, and anoxic brain damage due to difficulties in promptly establishing neonatal airway.  The ex utero intrapartum treatment (EXIT) procedure enables airway management while maintaining utero-placental circulation after partial delivery of the fetus via cesarean […]

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Uncategorized Published - 5 December, 2024    By - Dr Clemens
Science, Medicine, and the Anesthesiologist

Author: Charles Emala, M.D. Anesthesiology December 2024, Vol. 141, A13–A15. Mining human microbiomes reveals an untapped source of peptide antibiotics. Cell 2024; 187:5453–67. PMID: 39163860. Microbial resistance to antibiotics is an ever-present challenge in the management of infections and has traditionally been addressed by the reiterative synthesis of novel synthetic antibiotics. Antimicrobial peptide antibiotics are produced […]

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Uncategorized Published - 4 December, 2024    By - Dr Clemens
Cardiovascular Effects of Increasing Positive End-expiratory Pressure in a Model of Left Ventricular Cardiogenic Shock in Female Pigs

Authors: Oskar Kjærgaard Hørsdal, B.M.Sc. et al  Anesthesiology December 2024, Vol. 141, 1105–1118. Background Cardiogenic shock (CS) presents a medical challenge with limited treatment options. Positive end-expiratory pressure (PEEP) during mechanical ventilation has been linked with clinical benefits in patients with CS. This study investigated whether increasing PEEP levels could unload the left ventricle (LV) in […]

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Uncategorized Published - 4 December, 2024    By - Dr Clemens
Discover The Best Anesthesiologist Opportunity in New Mexico

We are seeking a dedicated anesthesiologist to join our all-anesthesiologist group. Our team will consist of 4 full-time providers and 1 for vacation relief, managing 3 operating rooms. Position Highlights: Zero call for 3 weeks, followed by 1 week of call without daytime work only call after 7 PM therefore you may not work the […]

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