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Authors: Jeffrey H. Silber, MD, PhD et al Anesthesiology May 2024. Background Observational studies of anesthetic neurotoxicity may be biased because children requiring anesthesia commonly have medical conditions associated with neurobehavioral problems. This study takes advantage of a natural experiment associated with appendicitis, in order to determine if anesthesia and surgery in childhood were specifically […]
Read MoreAuthors: David J. Douin, M.D.; Ana Fernandez-Bustamante, M.D., Ph.D., FASA. Anesthesiology June 2024, Vol. 140, 1238–1239. In Reply: We are grateful to Drs. Kowalczyk and Farber for their thorough review and insightful response to our recent clinical focused review of the administration of fibrinogen to mitigate endothelial dysfunction after acute traumatic injury. We appreciate their constructive critique regarding […]
Read MoreAuthors: John J. Kowalczyk, M.D.; Michaela K. Farber, M.D., M.S. Anesthesiology June 2024, Vol. 140, 1237–1238. To the Editor: We read with great interest the review of “Early Fibrinogen Replacement to Treat the Endotheliopathy of Trauma: Novel Resuscitation Strategies in Severe Trauma” by Douin et al. This article explores endothelial dysfunction that can occur with the coagulopathy of trauma, […]
Read MoreAuthors: Manuel C. Vallejo, M.D., D.M.D. et al Anesthesiology June 2024, Vol. 140, 1235–1236. To the Editor: Both parturients and healthcare providers have fears of neurologic complications associated with neuraxial analgesia/anesthesia, even though the odds are 5- to 10-fold higher for obstetric-related injury. More than half of parturients want to be informed of anesthetic risks even […]
Read MoreAuthors: Mathias Maagaard, M.D. et al Anesthesiology June 2024, Vol. 140, 1165–1175. Background Both dexamethasone and dexmedetomidine increase the duration of analgesia of peripheral nerve blocks. The authors hypothesized that combined intravenous dexamethasone and intravenous dexmedetomidine would result in a greater duration of analgesia when compared with intravenous dexamethasone alone and placebo. Methods The authors randomly […]
Read MoreAuthors: Alexandre Mansour, M.D., Ph.D. et al Anesthesiology June 2024, Vol. 140, 1153–1164. Background Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent on extracorporeal membrane oxygenation; however, its association with acquired antithrombin deficiency is poorly understood. The objective […]
Read MoreAuthors: Gaolin Qiu, M.D. et al Anesthesiology June 2024, Vol. 140, 1134–1152. Background Dexmedetomidine has repeatedly shown to improve anxiety, but the precise neural mechanisms underlying this effect remain incompletely understood. This study aims to explore the role of corticotropin-releasing hormone–producing hypothalamic paraventricular nucleus (CRHPVN) neurons in mediating the anxiolytic effects of dexmedetomidine. Methods A social […]
Read MoreAuthors: Aurora N. Quaye, M.D. et al Anesthesiology June 2024, Vol. 140, 1088–1097. Background Colorectal cancer is a leading cause of cancer-related death. Adenomas and serrated polyps are precursors of colorectal cancer, with serrated polyps being more difficult to detect during colonoscopy. The relationship between propofol use and polyp detection remains unclear. The authors investigated the […]
Read MoreAuthors: Ramón Eizaga Rebollar, M.D. et al Anesthesiology June 2024, Vol. 140, 1203–1204. Figure 1, B and C correspond to a healthy 2-yr-old boy who underwent hypospadias repair during general anesthesia combined with ultrasound-guided continuous caudal block. Mid-sagittal plane lumbar ultrasound (Sonosite SII, FUJIFILM Sonosite, Inc., USA) showed the dural sac end at S4 vertebral level, significantly lower for […]
Read MoreAuthors: Raquel Pereira-Silva, Ph.D. et al Anesthesiology June 2024, Vol. 140, 1176–1191. Background The dorsal reticular nucleus is a pain facilitatory area involved in diffuse noxious inhibitory control (DNIC) through opioidergic mechanisms that are poorly understood. The hypothesis was that signaling of μ-opioid receptors is altered in this area with prolonged chronic inflammatory pain and that […]
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