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Author: Michael R. Fettiplace, M.D., Ph.D. Anesthesiology May 2024, Vol. 140, 868–870. “[As] evidence accumulates, we find that the biologic plausibility of liposomal bupivacaine does not translate into clinical relevance.” For over a century, anesthesiologists have sought to extend the utility, duration, and safety of local anesthetics, from the original topical instillation of cocaine onto the […]
Read MoreAnesthesiology May 2024, Vol. 140, A13–A15. Cortical regulation of helping behaviour towards others in pain. Nature 2024; 626:136–44. PMID: 38267578. Article Selection: Cyril Rivat, Ph.D. Image: Adobe Stock. Prosocial behaviors are pivotal for promoting survival and social cohesion among animals. Injury triggers instinctive responses alleviating pain and reducing infection risks through behaviors like licking. In social […]
Read MoreAnesthesiology May 2024, Vol. 140, A13–A15. The impact of bed rest on human skeletal muscle metabolism. Cell Rep Med 2024; 5:101372. PMID: 38232697. Article Selection: Charles Emala, M.D. Image: Adobe Stock. Prolonged physical inactivity results in detrimental alterations in many physiologic processes including insulin insensitivity, but the kinetics and cellular mechanisms of these changes in human […]
Read MoreAuthors: Jessica C. Martin, Ph.D., B.Sc. (Hons.), B.Eng et al Anesthesiology May 2024, Vol. 140, 890–905. Background High-density electroencephalographic (EEG) monitoring remains underutilized in clinical anesthesia, despite its obvious utility in unraveling the profound physiologic impact of these agents on central nervous system functioning. In school-aged children, the routine practice of rapid induction with high concentrations […]
Read MoreAuthors: Michael Mazzeffi, M.D., M.P.H., M.Sc., F.A.S.A.; Jacob Gutsche, M.D. Anesthesiology May 2024, Vol. 140, 887–889. “Cardiac output cannot be accurately measured during veno-venous ECMO using traditional pulmonary artery catheter thermodilution because recirculation in the ECMO circuit tends to overestimate true cardiac output.” Veno-venous extracorporeal membrane oxygenation (ECMO) has become a widely accepted therapy for adults with […]
Read MoreAuthors: Nasir Hussain, M.D., M.Sc. et al Anesthesiology May 2024, Vol. 140, 906–919. Background Liposomal bupivacaine is reported to prolong the duration of analgesia when used for abdominal fascial plane blocks compared to plain local anesthetics; however, evidence from randomized trials is mixed. This meta-analysis aims to compare the analgesic effectiveness of liposomal bupivacaine to plain […]
Read MoreAuthor: James P. Rathmell, M.D. Anesthesiology May 2024, Vol. 140, 865–867. “Understanding that the scientific process is messy and imperfect, let’s heed the courts’ direction by continuing open and respectful debate in the published literature […].” It is New Year’s Day 2024, and I am in my office in Boston on the first day in my […]
Read MoreAuthors: Jonathan Slonin, M.D., M.B.A. et al Anesthesiology May 2024, Vol. 140, 874–876. “[M]eta-analyses play a primary role in evidence-based medicine, yet several pervasive challenges can undermine their interpretability […].” Systematic reviews and meta-analyses of randomized clinical trials are widely considered the highest level of clinical evidence. Because of their substantial influence on medical practice, meta-analyses […]
Read MoreAnesthesiology May 2024, Vol. 140, A13–A15. A placebo-controlled trial of percutaneous coronary intervention for stable angina. N Engl J Med 2023; 389:2319–30. PMID: 38015442. Article Selection: BobbieJean Sweitzer, M.D. Image: Adobe Stock. The efficacy of percutaneous coronary interventions (PCIs) on symptom relief in patients with stable angina on little or no antianginal medications is uncertain. This […]
Read MoreAuthors: Chen M et al Cureus 16(2): e55207. doi:10.7759/cureus.55207 Abstract Guillain-Barré syndrome (GBS) is a rare acute-onset neurological disease with significant morbidity and mortality. The risk of GBS increases after delivery. Labor and delivery presents many possible risk factors for GBS. However, risk factors and prognosis of postpartum GBS remain unclear due to its low incidence. Here, […]
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