Month: January 2024

Uncategorized Published - 8 January, 2024    By - Dr Clemens
Trends in Anesthesiology

New treatment for rare blood cancer The U.S. Food and Drug Administration (FDA) has approved Tibsovo (ivosidenib) for the treatment of adult patients with relapsed or refractory myelodysplastic syndromes (MDS) who have an isocitrate dehydrogenase-1 (IDH1) mutation. MDS is a rare form of blood cancer caused by mutations in bone marrow cells, leading to a […]

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Uncategorized Published - 8 January, 2024    By - Dr Clemens
Stress pathways induced by volatile anesthetics and failure of preconditioning in a mitochondrial Complex I mutant

Authors: Zachariah P.G. Olufs, B.S. et al  Anesthesiology December 2023. Background Carriers of mutations in the mitochondrial electron transport chain (mETC) are at increased risk of anesthetic-induced neurotoxicity. To investigate the neurotoxicity mechanism and to test preconditioning as a protective strategy, we used a Drosophila melanogaster model of Leigh syndrome. Model flies carried a mutation in ND23 (ND2360114) that encodes […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
User-Centered Design of a Machine Learning Dashboard for Prediction of Postoperative Complications

AUTHORS: Fritz, Bradley A. MD, MSCI et al   Anesthesia & Analgesia June 2023.  BACKGROUND: Machine learning models can help anesthesiology clinicians assess patients and make clinical and operational decisions, but well-designed human-computer interfaces are necessary for machine learning model predictions to result in clinician actions that help patients. Therefore, the goal of this study […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
Definition of Monitored Anesthesia Care

Authors: Dinesh Ramaiah MBBS et al  O THE EDITOR We appreciate the reprinting in the APSF Newsletter of the article from Anesthesia & Analgesia, (June 2022 • Volume 134 • Number 6, pages 1192–1200), entitled “Pro-Con Debate: Monitored Anesthesia Care Versus General Endotracheal Anesthesia for Endoscopic Retrograde Cholangiopancreatography” by Janik et al., and we hope that in reprinting […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
Updates from the Multi-center Handoff Collaborative

Authors: Aalok V. Agarwala, MD, MBA et al  The transition of responsibility and accountability for patient care from one clinical team to another is a routine part of modern health care delivery. Whether between physical locations (e.g., from the emergency department to an inpatient floor), or between teams in a static location (e.g., from a […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
Opioid Induced Respiratory Depression— Beyond Sleep Disordered Breathing

Author: Toby N. Weingarten, MD Anesthesia Patient Safety Foundation Volume 38, No. 2 • June 2023  More than a decade ago the APSF established a clear edict: “No patient should be harmed by opioid-induced respiratory depression in the postoperative period.”1 Research studies established a strong association between obstructive sleep apnea (OSA) and adverse postoperative opioid-related outcomes. In […]

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Uncategorized Published - 5 January, 2024    By - Dr Clemens
A Pharmacological Evaluation of the Analgesic Effect and Hippocampal Protein Modulation of the Ketamine Metabolite (2R,6R)-Hydroxynorketamine in Murine Pain Models

AUTHORS: Das, Vaskar PhD et al  Anesthesia & Analgesia June 2023. BACKGROUND: The ketamine metabolite (2R,6R)-hydroxynorketamine ([2R,6R]-HNK) has analgesic efficacy in murine models of acute, neuropathic, and chronic pain. The purpose of this study was to evaluate the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) dependence of (2R,6R)-HNK analgesia and protein changes in the hippocampus in murine pain models administered […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Trending Ability of End-Tidal Capnography Monitoring During Mechanical Ventilation to Track Changes in Arterial Partial Pressure of Carbon Dioxide in Critically Ill Patients With Acute Brain Injury

AUTHORS: Coëffic, Adrien MD et al  Anesthesia & Analgesia June 2023. BACKGROUND: Changes in arterial partial pressure of carbon dioxide (Paco2) may alter cerebral perfusion in critically ill patients with acute brain injury. Consequently, international guidelines recommend normocapnia in mechanically ventilated patients with acute brain injury. The measurement of end-tidal capnography (Etco2) allows its approximation. […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Prevalence and Persistence of Prescription Opioid Use Following Hospital Discharge After Childbirth

AUTHORS: Varney, Bianca MIPH et al  Anesthesia & Analgesia June 2023. BACKGROUND: Opioid analgesics are used for acute postpartum pain relief but carry risks, including persistent long-term opioid use. Our primary objective was to estimate the prevalence of persistent use following hospital discharge after childbirth. METHODS: We conducted a population-based cohort study of women discharged […]

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Uncategorized Published - 4 January, 2024    By - Dr Clemens
Is Continuous Intraoperative Monitoring of Mean Arterial Pressure as Good as the Hypotension Prediction Index Algorithm?

Authors: Marijn P. Mulder, M.Sc. et al  Anesthesiology June 2023, Vol. 138, 657–658. To the Editor: The Hypotension Prediction Index is a validated machine learning algorithm based on numerous characteristics of the arterial waveform and aimed at predicting hypotension up to 15 min in advance.  The recent special article by Enevoldsen and Vistisen focused on the data […]

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