Month: October 2023

Uncategorized Published - 2 October, 2023    By - Dr Clemens
Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium

Authors: Jacqueline M. Leung, M.D., M.P.H. et al  Anesthesiology October 2023, Vol. 139, 432–443. Background The pathophysiology of delirium is incompletely understood, including what molecular pathways are involved in brain vulnerability to delirium. This study examined whether preoperative plasma neurodegeneration markers were elevated in patients who subsequently developed postoperative delirium through a retrospective case-control study. Methods […]

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Uncategorized Published - 2 October, 2023    By - Dr Clemens
Opposing effects on descending control of nociception by mu and kappa opioid receptors in the anterior cingulate cortex

Authors: Edita Navratilova, Ph.D. et al  Anesthesiology September 2023. Background The efficiency of descending pain modulation, commonly assessed with the conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain. We hypothesized that the efficiency of pain modulation is controlled by cortical opioid circuits. Methods We evaluated the effects of mu opioid receptor […]

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