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Author: Heidi Splete Practical Pain Management People living with chronic migraine have a new oral option in the form of atogepant tablets. The FDA has approved an expanded indication of atogepant (Qulipta) to include the prevention of chronic migraine in adults, according to a statement from manufacturer AbbVie. Atogepant, an oral calcitonin gene-related peptide (CGRP) receptor […]
Read MoreAuthors: Sergiy M. Nadtochiy, Ph.D. et al Anesthesiology May 2023, Vol. 138, 523–532. Background Heparin anticoagulation has been used successfully for cardiopulmonary bypass (CPB). However, an alternative anticoagulant approach is desirable due to the cases of heparin-induced thrombocytopenia. Dabigatran provides anticoagulation for an in vitro model of simulated CPB. The current analysis tests the hypothesis that dabigatran provides […]
Read MoreAuthors: Niklas Larsson, M.D. et al Anesthesiology May 2023, Vol. 138, 561–563. To the Editor: Lipid mediators derived from arachidonic acid and other precursor polyunsaturated fatty acids, collectively known as oxylipins, are metabolized along different distinct pathways and play important roles in the modulation of inflammation. Blood oxylipin profiles have been shown to correlate with the survival […]
Read MoreRadius Anesthesia blog Anesthesia is an important part of many medical procedures, especially surgery. While most uses of anesthesia remain uneventful, accidents or mistakes may occur in rare cases, ranging from failing to understand a patient’s medical history to improperly administering anesthesia during a procedure 1. These can result in a wide range of injuries 2. Unintended injuries […]
Read MoreAuthors: Kelly E Michaelsen, MD PhD et al Anesthesiology April 2023. Background Mechanomyography is the traditional gold standard research technique for quantitative assessment of neuromuscular blockade. Mechanomyography directly measures the isometric force generated by the thumb in response to ulnar nerve stimulation. Researchers must construct their own mechanomyographs since commercial instruments are no longer available. […]
Read MoreAuthors: Bettinger J et al Pract Pain Manage. 2023 MayJune:23(2). In this series of analyses, we have broken down the various aspects of the newly released revisions to the CDC Clinical Practice Guideline for Prescribing Opioids for Pain to help clinicians, patients, and caretakers alike understand their nuances and to provide expert review of their applicability, potential […]
Read MoreAUTHORS: Carella, Michele MD et al Anesthesia & Analgesia 132(2):p 500-511, February 2021. BACKGROUND: The anesthetic management of supratentorial craniotomy (CR) necessitates tight intraoperative hemodynamic control. This type of surgery may also be associated with substantial postoperative pain. We aimed at evaluating the influence of regional scalp block (SB) on hemodynamic stability during the noxious events […]
Read MoreAuthors: Christian Mpody, M.D., Ph.D., M.P.H., M.B.A. et al Anesthesiology April 2023. To the Editor: Although pharmaceutical costs account for approximately 15% of the overall cost of anesthetic care, these expenses are frequently assumed to be due to the choice of anesthetic technique (general vs. regional) or the choice of medications used for anesthetic care. Seldom […]
Read MoreAuthors: Dong Zhang, PhD et al Anesthesiology April 2023. Background The administration of epinephrine after severe refractory hypotension, shock or cardiac arrest restores systemic blood flow and major vessel perfusion but may worsen cerebral microvascular perfusion and oxygen delivery through vasoconstriction. We hypothesized that epinephrine induces significant microvascular constriction in the brain, with increased severity […]
Read MoreСаrdiac Anesthesiologist April 2023 Propofol and thiopental sodium are both intravenous anesthetic agents used for the induction of anesthesia, but there are several differences between the two agents: Onset and duration of action: Propofol has a more rapid onset of action compared to thiopental sodium, meaning it takes effect more quickly after administration. Propofol also has […]
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