Authors: Helen Hoyt, BS et al Anesthesiology August 2022. Background Etomidate, barbiturates, alphaxalone, and propofol are anesthetics that allosterically modulate GABAA receptors via distinct sets of molecular binding sites. Two-state concerted co-agonist models account for anesthetic effects and predict supra-additive interactions between drug pairs acting at distinct sites. Some behavioral and molecular studies support these predictions, while other […]
Read MoreAuthors: Virginia E. Tangel, MA MSc et al Anesthesiology September 2022. Background There are multiple preoperative risk scores for pediatric mortality. The aim of this study was to systematically describe and compare the existing studies of patient-specific multispecialty risk prediction scores for perioperative mortality in pediatric populations, with the goal of guiding clinicians on which […]
Read MoreAuthor: Adam Felman MedicalNewsToday Leg pain can be due to trauma or a symptom of a condition. A person can receive treatment based on the specific cause of the leg pain. There are many causes of leg pain. Causes can relate to the following: blood vessels nerves muscles joints soft tissues bones The course of […]
Read MoreAuthor: Patsy Newitt Becker’s ASC Review Medscape’s 2022 “Employed Physicians Report” surveyed more than 1,350 physicians employed by healthcare organizations, hospitals, large group practices, clinics or other medical groups about their jobs. Here are 13 stats about employed physician salary: How employed physician compensation is structured: Salary only: 32 percent Salary, productivity targets and other metrics: […]
Read MoreAuthors: Johannes Enevoldsen, M.D.; Simon T. Vistisen, M.Sc., Ph.D. Anesthesiology September 2022, Vol. 137, 283–289. The Hypotension Prediction Index is a proprietary prediction model incorporated into a commercially available intraoperative hemodynamic monitoring system. The Hypotension Prediction Index uses multiple features of the arterial blood pressure waveform to predict hypotension. The index publication introducing the Hypotension Prediction Index […]
Read MoreAuthors: Geiger J, Bettinger J, Atkinson T. Opioid Peptides: A Review of Natural Substances with Opioid Effects. Pract Pain Manag. 2022 July/August;22(4). This review goes beyond poppies to the world of non-opiate opioid peptides, comparing their physio-chemical and pharmacologic profiles, and discussing their potential for future development and use in pain management. Traditional opioid medications […]
Read MoreDG Journal Club AUTHORS: Jesus Pujol, Gerard Martínez-Vilavella, Lluís Gallart, Laura Blanco-Hinojo Br J Anaesth. 2022 Aug 13 BACKGROUND The safety of anaesthesia has improved as a result of better control of anaesthetic depth. However, conventional monitoring does not inform on the nature of nociceptive processes during unconsciousness. A means of inferring the quality of […]
Read MoreDG Journal Club AUTHORS: Tor-Arne Hegvik, Kari Klungsøyr, Ralf Kuja-Halkola, Hanna Remes Am J Obstet Gynecol. 2022 Aug 13 BACKGROUND A recent study has suggested that labor epidural analgesia may be associated with increased rates of offspring autism spectrum disorder (ASD). Subsequent replication attempts have lacked sufficient power to confidently exclude the possibility of a […]
Read MoreDG Journal Club AUTHORS: Charles H Brown, Alexandria Lewis, Julia Probert, Michelle Parish Anesthesiology. 2022 Aug 19 BACKGROUND Neurofilament light is a marker of neuronal injury and can be measured in blood. Postoperative increases in neurofilament light have been associated with delirium after noncardiac surgery. However, few studies have examined the association of neurofilament light […]
Read MoreAuthors: Spencer P. Walsh, M.D. et al Anesthesiology August 2022. After the landmark Acute Respiratory Distress Syndrome Network study in 2000, the idea of low tidal volume (VT) ventilation spread through the critical care and anesthesiology communities. Studies have shown that positive-pressure ventilation contributes to lung inflammation and might predispose general surgery and intensive care unit […]
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