Month: June 2022

Uncategorized Published - 9 June, 2022    By - Dr Clemens
Ketamine Psychedelic and Antinociceptive Effects Are Connected

Authors: Erik Olofsen, Ph.D. et al  Anesthesiology May 2022, Vol. 136, 792–801. Background Ketamine produces potent analgesia combined with psychedelic effects. It has been suggested that these two effects are associated and possibly that analgesia is generated by ketamine-induced dissociation. The authors performed a post hoc analysis of previously published data to quantify the pharmacodynamic properties of ketamine-induced […]

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Uncategorized Published - 8 June, 2022    By - Dr Clemens
Stuck in a Rut: Anesthetic Brain Dynamics in the Young

Author: Jamie W. Sleigh, M.D. Anesthesiology July 2022, Vol. 137, 4–5. “General anesthesia had rendered the brains of the young patients functionally ‘rigid,’ [which] contrasts with a previous study in adults.” Every human would agree that wakefulness is marked by a succession of experiences—the “stream-of-consciousness.” This implies that the state of the brain is continuously changing […]

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Uncategorized Published - 8 June, 2022    By - Dr Clemens
Combination Therapy of High-flow Nasal Cannula and Upper-body Elevation for Postoperative Sleep-disordered Breathing: Randomized Crossover Trial

Authors: Yuichi Sakaguchi, M.D. et al  Anesthesiology July 2022, Vol. 137, 15–27. Background The low acceptance rate of continuous positive airway pressure therapy in postoperative patients with untreated obstructive sleep apnea (OSA) indicates the necessity for development of an alternative postoperative airway management strategy. The authors considered whether the combination of high-flow nasal cannula and upper-body […]

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Uncategorized Published - 8 June, 2022    By - Dr Clemens
Anesthetic MAC: Origin, Utility, and Nomenclature Revisited

Author: Evan D. Kharasch, M.D., Ph.D. Anesthesiology June 2022, Vol. 136, 885–887. “It is time to call a MAC (minimum alveolar concentration) a MAC (median alveolar concentration).” Anesthesiology is a specialty grounded in basic and clinical pharmacology. These domains have concepts and vocabularies that are useful to scientists and clinicians, in their understanding and application of […]

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Uncategorized Published - 8 June, 2022    By - Dr Clemens
Surgeon Variation in Perioperative Opioid Prescribing and Medium- or Long-term Opioid Utilization after Total Knee Arthroplasty

Authors: Xi Cen, Ph.D. et al  Anesthesiology June 2022. Background Whether a particular surgeon’s opioid prescribing behavior is associated with prolonged postoperative opioid use is unknown. This study tested the hypothesis that the patients of surgeons with a higher propensity to prescribe opioids are more likely to utilize opioids long-term postoperatively. Methods The study identified […]

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Uncategorized Published - 8 June, 2022    By - Dr Clemens
Dynamic Obstruction due to Unfurling of Spirals in a Flexometallic Tube

Authors: Shwethashri Kondavagilu Ramaprasannakumar, M.D., D.M. et al Anesthesiology July 2022, Vol. 137, 79–80. Flexometallic tubes are kink-resistant and extensively used in neurosurgeries. The manufacturers of flexometallic tubes recommend single usage. In low-income countries, due to the cost restraints, flexometallic tubes are commonly reused after ethylene oxide sterilization. With this technique, flexometallic tubes are effectively […]

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Uncategorized Published - 7 June, 2022    By - Dr Clemens
Carbon Footprint of Anesthesia: Comment

Authors: Quentin Gobert, M.D., D.E.S.A.R.; Lyndia Dernis, M.D., D.E.S.A.R. Anesthesiology July 2022, Vol. 137, 118–119. To the Editor: We read with interest the article by Mc Gain et al. presenting the comparative carbon footprint of two general and regional anesthesia techniques. As the authors point out, the results cannot be systematically extrapolated to other countries because of the […]

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Uncategorized Published - 7 June, 2022    By - Dr Clemens
Carbon Footprint of Anesthesia: Comment

Authors: Mitchell H. Tsai, M.D., M.M.M., F.A.S.A., F.A.A.C.D. et al  Anesthesiology July 2022, Vol. 137, 119–120. To the Editor: Using life cycle assessments, McGain et al.  account for the carbon footprint of general, regional, and combined anesthesia techniques for total joint replacements in Australia. With the accounting of carbon emissions, we applaud the authors for demonstrating that the […]

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Uncategorized Published - 7 June, 2022    By - Dr Clemens
Carbon Footprint of Anesthesia: Comment

Author: Jane Carter, M.B.B.S., B.Med.Sci., D.T.M.H., F.A.N.Z.C.A.; Jess Davies, M.B.B.S. (Hons.), M.Sc., F.A.N.Z.C.A. Anesthesiology July 2022, Vol. 137, 121. To the Editor: The article “Carbon Footprint of General, Regional, and Combined Anesthesia for Total Knee Replacement” by McGain et al.  provides welcome dialogue in the evidence-sparse domain of carbon equivalent comparisons between anesthetic modalities. Their paper describes prospective […]

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Uncategorized Published - 7 June, 2022    By - Dr Clemens
Carbon Footprint of Anesthesia: Comment

Authors: Kristopher M. Schroeder, M.D., F.A.S.A. et al Anesthesiology July 2022, Vol. 137, 122. To the Editor: We read with great interest the recent article by McGain et al.1  that quantified the carbon footprint associated with the provision of spinal anesthesia and general anesthesia for total knee arthroplasty. This type of encompassing evaluation is valuable as it is […]

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