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Authors: Tiffany Sun Moon, MD and Albert J. Varon, MD, MHPE, FCCM, FASA ASA Monitor March 2022, Vol. 86, 33–34. Tranexamic acid (TXA) is an antifibrinolytic agent that competitively inhibits the activation of plasminogen to plasmin, stabilizing previously formed clots (J Thromb Haemost 2015;13:S195-9; Eur J Haematol 2020;104:79-87; Crit Care Clin 2017;33:85-99). TXA has been well studied in non-trauma […]
Read MoreAuthors: Laura Girón-Arango, MD et al ASA Monitor March 2022, Vol. 86, 31–32. Point-of-care ultrasound (POCUS) in trauma was introduced early with the Focused Assessment with Sonography for Trauma (FAST) exam, a well-known scanning protocol incorporated into the Advanced Trauma Life Support® program to help with the diagnosis of life-threatening situations during the primary survey. The […]
Read MoreAuthors: Chung-Sik Oh, M.D., Ph.D. et al Anesthesiology March 2022, Vol. 136, 448–458. Background The antitumor effects of natural killer cells, helper T cells, and cytotoxic T cells after cancer surgery were reported previously. This study hypothesized that propofol-based anesthesia would have fewer harmful effects on immune cells than volatile anesthetics–based anesthesia during colorectal cancer […]
Read MoreAuthors: Thomas E. Grissom, MD, MSIS, FASA, FCCM and Kevin P. Blaine, MD, MPH, FASA ASA Monitor March 2022, Vol. 86, 29–30. Uncontrolled hemorrhage requiring emergent surgery after major trauma continues to be a contributor to perioperative death (Intensive Care Med 2019;45:709-11). While most hemorrhage deaths occur before injured patients reach the hospital, advancement in medical […]
Read MoreAuthors: Eric McDaniel, MD and Joseph McIsaac, III, MD, MS, MBA, CPE, FASA ASA Monitor March 2022, Vol. 86, 28–29. Chemical, biological, radiological, and nuclear (CBRN) events occur often in concert with traumatic injuries; however, a large majority of CBRN literature and research frequently exclude the trauma perspective (Expert Opin Ther Pat 2016;26:1431-47; Expert Opin Ther Pat 2016;26:1399-1408). […]
Read MoreAuthors: Anna Maria Bombardieri, M.D., Ph.D. and Ban C. H. Tsui, M.D., M.Sc. Anesthesiology May 2022, Vol. 136, 867–868. To the Editor: We read with great interest the study by Koch et al.,1 which concluded that “ephedrine results in better brain microcirculation and oxygen delivery than phenylephrine” and raised “concerns regarding phenylephrine for blood pressure augmentation in patients […]
Read MoreAuthors: Klaus Ulrik Koch, M.D., Ph.D. and Mads Rasmussen, M.D., Ph.D. Anesthesiology May 2022, Vol. 136, 868. In Reply: We thank Bombardieri and Tsui1 for their excellent comments and interest in our study.2 We agree with Bombardieri and Tsui that the deterioration of microperfusion and possibly tissue oxygenation after phenylephrine administration in the “healthy” brain hemisphere2 indicates that different vasopressors […]
Read MoreAuthors: Rebecca M. Pullon, Ph.D. et al Anesthesiology March 2022, Vol. 136, 420–433. Background The wakeful brain can easily access and coordinate a large repertoire of different states—dynamics suggestive of “criticality.” Anesthesia causes loss of criticality at the level of electroencephalogram waveforms, but the criticality of brain network connectivity is less well studied. The authors […]
Read MoreAuthors: Cecilie Holse, M.D. et al Anesthesiology March 2022, Vol. 136, 408–419. Background Hyperoxia and oxidative stress may be associated with increased risk of myocardial injury. The authors hypothesized that a perioperative inspiratory oxygen fraction of 0.80 versus 0.30 would increase the degree of myocardial injury within the first 3 days of surgery, and that an antioxidant […]
Read MoreAuthors: Amr E. Abouleish, M.D., M.B.A. et al Anesthesiology May 2022, Vol. 136, 864–865. To the Editor: We read with great interest the review article on the American Society of Anesthesiologists (ASA; Schaumburg, Illinois) Physical Status Classification System by Horvath et al. The review presents in excellent detail the origin, evolution, and current state of the ASA […]
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